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Morita-Baylis-Hillman adduct 2-(3-hydroxy-1-methyl-2-oxoindolin-3-il) acrylonitrile (CISACN) ameliorates the pulmonary allergic inflammation in CARAS model by increasing IFN-γ/IL-4 ratio towards the Th1 immune response.
Adilis Maria Paiva Ferreira L, Karla Diega Paiva Ferreira L, Fragoso Pereira Cavalcanti R, Allysson de Assis Ferreira Gadelha F, Mangueira de Lima L, Francisco Alves A, Gabriel Lima Júnior C, Regina Piuvezam M. Adilis Maria Paiva Ferreira L, et al. Int Immunopharmacol. 2024 Mar 30;130:111737. doi: 10.1016/j.intimp.2024.111737. Epub 2024 Feb 24. Int Immunopharmacol. 2024. PMID: 38401465