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Quantitative live cell imaging of a tauopathy model enables the identification of a polypharmacological drug candidate that restores physiological microtubule interaction.
Pinzi L, Conze C, Bisi N, Torre GD, Soliman A, Monteiro-Abreu N, Trushina NI, Krusenbaum A, Dolouei MK, Hellwig A, Christodoulou MS, Passarella D, Bakota L, Rastelli G, Brandt R. Pinzi L, et al. Among authors: conze c. Nat Commun. 2024 Feb 23;15(1):1679. doi: 10.1038/s41467-024-45851-6. Nat Commun. 2024. PMID: 38396035 Free PMC article.
Super-resolution imaging and quantitative analysis of microtubule arrays in model neurons show that epothilone D increases the density but decreases the length and straightness of microtubules in axon-like processes.
Conze C, Trushina NI, Holtmannspötter M, Rierola M, Attanasio S, Bakota L, Piehler J, Brandt R. Conze C, et al. Brain Res Bull. 2022 Nov;190:234-243. doi: 10.1016/j.brainresbull.2022.10.008. Epub 2022 Oct 13. Brain Res Bull. 2022. PMID: 36244582 Free PMC article.
The proteasome modulates endocytosis specifically in glomerular cells to promote kidney filtration.
Sachs W, Blume L, Loreth D, Schebsdat L, Hatje F, Koehler S, Wedekind U, Sachs M, Zieliniski S, Brand J, Conze C, Florea BI, Heppner F, Krüger E, Rinschen MM, Kretz O, Thünauer R, Meyer-Schwesinger C. Sachs W, et al. Among authors: conze c. Nat Commun. 2024 Mar 1;15(1):1897. doi: 10.1038/s41467-024-46273-0. Nat Commun. 2024. PMID: 38429282 Free PMC article.