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Structural Basis for Multivalent MUC16 Recognition and Robust Anti-Pancreatic Cancer Activity of Humanized Antibody AR9.6.
Aguilar EN, Sagar S, Murray BR, Rajesh C, Lei EK, Michaud SA, Goodlett DR, Caffrey TC, Grandgenett PM, Swanson B, Brooks TM, Black AR, van Faassen H, Hussack G, Henry KA, Hollingsworth MA, Brooks CL, Radhakrishnan P. Aguilar EN, et al. Among authors: brooks cl. Mol Cancer Ther. 2024 Jun 4;23(6):836-853. doi: 10.1158/1535-7163.MCT-23-0868. Mol Cancer Ther. 2024. PMID: 38394685
ImmunoPET of Ovarian and Pancreatic Cancer with AR9.6, a Novel MUC16-Targeted Therapeutic Antibody.
Sharma SK, Mack KN, Piersigilli A, Pourat J, Edwards KJ, Keinänen O, Jiao MS, Zhao H, White B, Brooks CL, de Stanchina E, Madiyalakan MR, Hollingsworth MA, Radhakrishnan P, Lewis JS, Zeglis BM. Sharma SK, et al. Among authors: brooks cl. Clin Cancer Res. 2022 Mar 1;28(5):948-959. doi: 10.1158/1078-0432.CCR-21-1798. Clin Cancer Res. 2022. PMID: 34907079 Free PMC article.
Antibody recognition of a unique tumor-specific glycopeptide antigen.
Brooks CL, Schietinger A, Borisova SN, Kufer P, Okon M, Hirama T, Mackenzie CR, Wang LX, Schreiber H, Evans SV. Brooks CL, et al. Proc Natl Acad Sci U S A. 2010 Jun 1;107(22):10056-61. doi: 10.1073/pnas.0915176107. Epub 2010 May 17. Proc Natl Acad Sci U S A. 2010. PMID: 20479270 Free PMC article.
Subtle Changes in the Combining Site of the Chlamydiaceae-Specific mAb S25-23 Increase the Antibody-Carbohydrate Binding Affinity by an Order of Magnitude.
Haji-Ghassemi O, Müller-Loennies S, Brooks CL, MacKenzie CR, Caveney N, Van Petegem F, Brade L, Kosma P, Brade H, Evans SV. Haji-Ghassemi O, et al. Among authors: brooks cl. Biochemistry. 2019 Feb 12;58(6):714-726. doi: 10.1021/acs.biochem.8b00318. Epub 2019 Jan 10. Biochemistry. 2019. PMID: 30571096
466 results