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1,102 results

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Page 1
Discovery of novel orexin receptor antagonists using a 1,3,5-trioxazatriquinane bearing multiple effective residues (TriMER) library.
Saitoh T, Amezawa M, Horiuchi J, Nagumo Y, Yamamoto N, Kutsumura N, Ohshita R, Tokuda A, Irukayama-Tomobe Y, Ogawa Y, Ishikawa Y, Hasegawa E, Sakurai T, Uchida Y, Sato T, Gouda H, Tanimura R, Yanagisawa M, Nagase H. Saitoh T, et al. Eur J Med Chem. 2022 Oct 5;240:114505. doi: 10.1016/j.ejmech.2022.114505. Epub 2022 Jun 13. Eur J Med Chem. 2022. PMID: 35839689
OX2R-selective orexin agonism is sufficient to ameliorate cataplexy and sleep/wake fragmentation without inducing drug-seeking behavior in mouse model of narcolepsy.
Yamamoto H, Nagumo Y, Ishikawa Y, Irukayama-Tomobe Y, Namekawa Y, Nemoto T, Tanaka H, Takahashi G, Tokuda A, Saitoh T, Nagase H, Funato H, Yanagisawa M. Yamamoto H, et al. Among authors: saitoh t. PLoS One. 2022 Jul 22;17(7):e0271901. doi: 10.1371/journal.pone.0271901. eCollection 2022. PLoS One. 2022. PMID: 35867683 Free PMC article.
Design and Synthesis of Orexin 1 Receptor-Selective Agonists.
Iio K, Hashimoto K, Nagumo Y, Amezawa M, Hasegawa T, Yamamoto N, Kutsumura N, Takeuchi K, Ishikawa Y, Yamamoto H, Tokuda A, Sato T, Uchida Y, Inoue A, Tanimura R, Yanagisawa M, Nagase H, Saitoh T. Iio K, et al. Among authors: saitoh t. J Med Chem. 2023 Apr 27;66(8):5453-5464. doi: 10.1021/acs.jmedchem.2c01773. Epub 2023 Apr 12. J Med Chem. 2023. PMID: 37043436
Unexpected Rearrangement Reactions of the 14-Aminonaltrexone Skeleton.
Maeda K, Ohrui S, Tokuda A, Nagumo Y, Yamamoto N, Tanimura R, Saitoh T, Kutsumura N, Nagase H. Maeda K, et al. Among authors: saitoh t. Org Lett. 2023 May 19;25(19):3407-3411. doi: 10.1021/acs.orglett.3c00956. Epub 2023 May 8. Org Lett. 2023. PMID: 37154730
The delta opioid receptor agonist KNT-127 relieves innate anxiety-like behavior in mice by suppressing transmission from the prelimbic cortex to basolateral amygdala.
Kawaminami A, Yamada D, Yoshioka T, Hatakeyama A, Nishida M, Kajino K, Saitoh T, Nagase H, Saitoh A. Kawaminami A, et al. Among authors: saitoh t, saitoh a. Neuropsychopharmacol Rep. 2024 Mar;44(1):256-261. doi: 10.1002/npr2.12406. Epub 2023 Dec 29. Neuropsychopharmacol Rep. 2024. PMID: 38156409 Free PMC article.
Design and Synthesis of Potent and Highly Selective Orexin 1 Receptor Antagonists with a Morphinan Skeleton and Their Pharmacologies.
Nagase H, Yamamoto N, Yata M, Ohrui S, Okada T, Saitoh T, Kutsumura N, Nagumo Y, Irukayama-Tomobe Y, Ishikawa Y, Ogawa Y, Hirayama S, Kuroda D, Watanabe Y, Gouda H, Yanagisawa M. Nagase H, et al. Among authors: saitoh t. J Med Chem. 2017 Feb 9;60(3):1018-1040. doi: 10.1021/acs.jmedchem.6b01418. Epub 2017 Jan 18. J Med Chem. 2017. PMID: 28051300
Essential structure of orexin 1 receptor antagonist YNT-707, Part IV: The role of D-ring in 4,5-epoxymorphinan on the orexin 1 receptor antagonistic activity.
Saitoh T, Seki K, Nakajima R, Yamamoto N, Kutsumura N, Nagumo Y, Irukayama-Tomobe Y, Ogawa Y, Ishikawa Y, Tanimura R, Yanagisawa M, Nagase H. Saitoh T, et al. Bioorg Med Chem Lett. 2019 Sep 15;29(18):2655-2658. doi: 10.1016/j.bmcl.2019.07.039. Epub 2019 Jul 24. Bioorg Med Chem Lett. 2019. PMID: 31375290
1,102 results