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Contractility defects hinder glycoprotein VI-mediated platelet activation and affect platelet functions beyond clot contraction.
Kenny M, Pollitt AY, Patil S, Hiebner DW, Smolenski A, Lakic N, Fisher R, Alsufyani R, Lickert S, Vogel V, Schoen I. Kenny M, et al. Among authors: pollitt ay. Res Pract Thromb Haemost. 2024 Jan 22;8(1):102322. doi: 10.1016/j.rpth.2024.102322. eCollection 2024 Jan. Res Pract Thromb Haemost. 2024. PMID: 38379711 Free PMC article.
Corrigendum to Contractility defects hinder glycoprotein VI-mediated platelet activation and affect platelet functions beyond clot contraction [Research and Practice in Thrombosis and Haemostasis Volume 8, Issue 1, January 2024, 102322].
Kenny M, Pollitt AY, Patil S, Hiebner DW, Smolenski A, Lakic N, Fisher R, Alsufyani R, Lickert S, Vogel V, Schoen I. Kenny M, et al. Among authors: pollitt ay. Res Pract Thromb Haemost. 2024 Apr 22;8(3):102414. doi: 10.1016/j.rpth.2024.102414. eCollection 2024 Mar. Res Pract Thromb Haemost. 2024. PMID: 38680968 Free PMC article.
Divalent nanobodies to platelet CLEC-2 can serve as agonists or antagonists.
Clark JC, Martin EM, Morán LA, Di Y, Wang X, Zuidscherwoude M, Brown HC, Kavanagh DM, Hummert J, Eble JA, Nieswandt B, Stegner D, Pollitt AY, Herten DP, Tomlinson MG, García A, Watson SP. Clark JC, et al. Among authors: pollitt ay. Commun Biol. 2023 Apr 7;6(1):376. doi: 10.1038/s42003-023-04766-6. Commun Biol. 2023. PMID: 37029319 Free PMC article.
Katacine Is a New Ligand of CLEC-2 that Acts as a Platelet Agonist.
Morán LA, Di Y, Sowa MA, Hermida-Nogueira L, Barrachina MN, Martin E, Clark JC, Mize TH, Eble JA, Moreira D, Pollitt AY, Loza MI, Domínguez E, Watson SP, García Á. Morán LA, et al. Among authors: pollitt ay. Thromb Haemost. 2022 Aug;122(8):1361-1368. doi: 10.1055/a-1772-1069. Epub 2022 Feb 15. Thromb Haemost. 2022. PMID: 35170009 Free PMC article.
Low-dose Btk inhibitors selectively block platelet activation by CLEC-2.
Nicolson PLR, Nock SH, Hinds J, Garcia-Quintanilla L, Smith CW, Campos J, Brill A, Pike JA, Khan AO, Poulter NS, Kavanagh DM, Watson S, Watson CN, Clifford H, Huissoon AP, Pollitt AY, Eble JA, Pratt G, Watson SP, Hughes CE. Nicolson PLR, et al. Among authors: pollitt ay. Haematologica. 2021 Jan 1;106(1):208-219. doi: 10.3324/haematol.2019.218545. Haematologica. 2021. PMID: 31949019 Free PMC article.
Interspecies differences in protein expression do not impact the spatiotemporal regulation of glycoprotein VI mediated activation.
Dunster JL, Unsworth AJ, Bye AP, Haining EJ, Sowa MA, Di Y, Sage T, Pallini C, Pike JA, Hardy AT, Nieswandt B, García Á, Watson SP, Poulter NS, Gibbins JM, Pollitt AY. Dunster JL, et al. Among authors: pollitt ay. J Thromb Haemost. 2020 Feb;18(2):485-496. doi: 10.1111/jth.14673. Epub 2019 Dec 6. J Thromb Haemost. 2020. PMID: 31680418 Free PMC article.
Inhibition of Btk by Btk-specific concentrations of ibrutinib and acalabrutinib delays but does not block platelet aggregation mediated by glycoprotein VI.
Nicolson PLR, Hughes CE, Watson S, Nock SH, Hardy AT, Watson CN, Montague SJ, Clifford H, Huissoon AP, Malcor JD, Thomas MR, Pollitt AY, Tomlinson MG, Pratt G, Watson SP. Nicolson PLR, et al. Among authors: pollitt ay. Haematologica. 2018 Dec;103(12):2097-2108. doi: 10.3324/haematol.2018.193391. Epub 2018 Jul 19. Haematologica. 2018. PMID: 30026342 Free PMC article.
33 results