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Bovine ultralong CDR-H3 derived knob paratopes elicit potent TNF-α neutralization and enable the generation of novel adalimumab-based antibody architectures with augmented features.
Arras P, Zimmermann J, Lipinski B, Valldorf B, Evers A, Elter D, Krah S, Doerner A, Guarnera E, Siegmund V, Kolmar H, Pekar L, Zielonka S. Arras P, et al. Among authors: valldorf b. Biol Chem. 2024 Feb 20. doi: 10.1515/hsz-2023-0370. Online ahead of print. Biol Chem. 2024. PMID: 38373142 Free article.
Cattle-derived knob paratopes grafted onto peripheral loops of the IgG1 Fc region enable the generation of a novel symmetric bispecific antibody format.
Yanakieva D, Vollmer L, Evers A, Siegmund V, Arras P, Pekar L, Doerner A, Valldorf B, Kolmar H, Zielonka S, Krah S. Yanakieva D, et al. Among authors: valldorf b. Front Immunol. 2023 Oct 24;14:1238313. doi: 10.3389/fimmu.2023.1238313. eCollection 2023. Front Immunol. 2023. PMID: 37942319 Free PMC article.
Rapid cGMP manufacturing of COVID-19 monoclonal antibody using stable CHO cell pools.
Agostinetto R, Rossi M, Dawson J, Lim A, Simoneau MH, Boucher C, Valldorf B, Ross-Gillespie A, Jardine JG, Sok D, Burton DR, Hassell T, Broly H, Palinsky W, Dupraz P, Feinberg M, Dey AK. Agostinetto R, et al. Among authors: valldorf b. Biotechnol Bioeng. 2022 Feb;119(2):663-666. doi: 10.1002/bit.27995. Epub 2021 Dec 10. Biotechnol Bioeng. 2022. PMID: 34796474 Free PMC article.
Antibody display technologies: selecting the cream of the crop.
Valldorf B, Hinz SC, Russo G, Pekar L, Mohr L, Klemm J, Doerner A, Krah S, Hust M, Zielonka S. Valldorf B, et al. Biol Chem. 2021 Mar 23;403(5-6):455-477. doi: 10.1515/hsz-2020-0377. Print 2022 Apr 26. Biol Chem. 2021. PMID: 33759431 Free article. Review.
Affinity Maturation of B7-H6 Translates into Enhanced NK Cell-Mediated Tumor Cell Lysis and Improved Proinflammatory Cytokine Release of Bispecific Immunoligands via NKp30 Engagement.
Pekar L, Klausz K, Busch M, Valldorf B, Kolmar H, Wesch D, Oberg HH, Krohn S, Boje AS, Gehlert CL, Toleikis L, Krah S, Gupta T, Rabinovich B, Zielonka S, Peipp M. Pekar L, et al. Among authors: valldorf b. J Immunol. 2021 Jan 1;206(1):225-236. doi: 10.4049/jimmunol.2001004. Epub 2020 Dec 2. J Immunol. 2021. PMID: 33268483 Free PMC article.
16 results