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Novel Dual-Acting Hybrids Targeting Type-2 Cannabinoid Receptors and Cholinesterase Activity Show Neuroprotective Effects In Vitro and Amelioration of Cognitive Impairment In Vivo.
Mugnaini C, Brizzi A, Paolino M, Scarselli E, Castelli R, de Candia M, Gambacorta N, Nicolotti O, Kostrzewa M, Kumar P, Mahmoud AM, Borgonetti V, Iannotta M, Morace A, Galeotti N, Maione S, Altomare CD, Ligresti A, Corelli F. Mugnaini C, et al. Among authors: ligresti a. ACS Chem Neurosci. 2024 Mar 6;15(5):955-971. doi: 10.1021/acschemneuro.3c00656. Epub 2024 Feb 19. ACS Chem Neurosci. 2024. PMID: 38372253
CB2-selective cannabinoid receptor ligands: synthesis, pharmacological evaluation, and molecular modeling investigation of 1,8-Naphthyridin-2(1H)-one-3-carboxamides.
Lucchesi V, Hurst DP, Shore DM, Bertini S, Ehrmann BM, Allarà M, Lawrence L, Ligresti A, Minutolo F, Saccomanni G, Sharir H, Macchia M, Di Marzo V, Abood ME, Reggio PH, Manera C. Lucchesi V, et al. Among authors: ligresti a. J Med Chem. 2014 Nov 13;57(21):8777-91. doi: 10.1021/jm500807e. Epub 2014 Oct 15. J Med Chem. 2014. PMID: 25272206 Free PMC article.
New quinolone- and 1,8-naphthyridine-3-carboxamides as selective CB2 receptor agonists with anticancer and immuno-modulatory activity.
Manera C, Malfitano AM, Parkkari T, Lucchesi V, Carpi S, Fogli S, Bertini S, Laezza C, Ligresti A, Saccomanni G, Savinainen JR, Ciaglia E, Pisanti S, Gazzerro P, Di Marzo V, Nieri P, Macchia M, Bifulco M. Manera C, et al. Among authors: ligresti a. Eur J Med Chem. 2015 Jun 5;97:10-8. doi: 10.1016/j.ejmech.2015.04.034. Epub 2015 Apr 24. Eur J Med Chem. 2015. PMID: 25935384
The endocannabinoid signalling system: biochemical aspects.
Bisogno T, Ligresti A, Di Marzo V. Bisogno T, et al. Among authors: ligresti a. Pharmacol Biochem Behav. 2005 Jun;81(2):224-38. doi: 10.1016/j.pbb.2005.01.027. Pharmacol Biochem Behav. 2005. PMID: 15935454 Review.
Investigations on the 4-quinolone-3-carboxylic acid motif. 2. Synthesis and structure-activity relationship of potent and selective cannabinoid-2 receptor agonists endowed with analgesic activity in vivo.
Pasquini S, Botta L, Semeraro T, Mugnaini C, Ligresti A, Palazzo E, Maione S, Di Marzo V, Corelli F. Pasquini S, et al. Among authors: ligresti a. J Med Chem. 2008 Aug 28;51(16):5075-84. doi: 10.1021/jm800552f. Epub 2008 Aug 5. J Med Chem. 2008. PMID: 18680276
Synthesis, cannabinoid receptor affinity, molecular modeling studies and in vivo pharmacological evaluation of new substituted 1-aryl-5-(1H-pyrrol-1-yl)-1H-pyrazole-3-carboxamides. 2. Effect of the 3-carboxamide substituent on the affinity and selectivity profile.
Silvestri R, Ligresti A, La Regina G, Piscitelli F, Gatti V, Brizzi A, Pasquini S, Lavecchia A, Allarà M, Fantini N, Carai MA, Novellino E, Colombo G, Di Marzo V, Corelli F. Silvestri R, et al. Among authors: ligresti a. Bioorg Med Chem. 2009 Aug 1;17(15):5549-64. doi: 10.1016/j.bmc.2009.06.027. Epub 2009 Jun 21. Bioorg Med Chem. 2009. PMID: 19595596
129 results