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Tropomyosin1 isoforms underlie epithelial to mesenchymal plasticity, metastatic dissemination, and resistance to chemotherapy in high-grade serous ovarian cancer.
Xu T, Verhagen MP, Teeuwssen M, Sun W, Joosten R, Sacchetti A, Ewing-Graham PC, Jansen MPHM, Boere IA, Bryce NS, Zeng J, Treutlein HR, Hook J, Hardeman EC, Gunning PW, Fodde R. Xu T, et al. Among authors: zeng j. Cell Death Differ. 2024 Mar;31(3):360-377. doi: 10.1038/s41418-024-01267-9. Epub 2024 Feb 16. Cell Death Differ. 2024. PMID: 38365970 Free PMC article.
A novel class of anticancer compounds targets the actin cytoskeleton in tumor cells.
Stehn JR, Haass NK, Bonello T, Desouza M, Kottyan G, Treutlein H, Zeng J, Nascimento PR, Sequeira VB, Butler TL, Allanson M, Fath T, Hill TA, McCluskey A, Schevzov G, Palmer SJ, Hardeman EC, Winlaw D, Reeve VE, Dixon I, Weninger W, Cripe TP, Gunning PW. Stehn JR, et al. Among authors: zeng j. Cancer Res. 2013 Aug 15;73(16):5169-82. doi: 10.1158/0008-5472.CAN-12-4501. Cancer Res. 2013. PMID: 23946473
On-target action of anti-tropomyosin drugs regulates glucose metabolism.
Kee AJ, Chagan J, Chan JY, Bryce NS, Lucas CA, Zeng J, Hook J, Treutlein H, Laybutt DR, Stehn JR, Gunning PW, Hardeman EC. Kee AJ, et al. Among authors: zeng j. Sci Rep. 2018 Mar 15;8(1):4604. doi: 10.1038/s41598-018-22946-x. Sci Rep. 2018. PMID: 29545590 Free PMC article.
Identification of Cancer-Targeted Tropomyosin Inhibitors and Their Synergy with Microtubule Drugs.
Currier MA, Stehn JR, Swain A, Chen D, Hook J, Eiffe E, Heaton A, Brown D, Nartker BA, Eaves DW, Kloss N, Treutlein H, Zeng J, Alieva IB, Dugina VB, Hardeman EC, Gunning PW, Cripe TP. Currier MA, et al. Among authors: zeng j. Mol Cancer Ther. 2017 Aug;16(8):1555-1565. doi: 10.1158/1535-7163.MCT-16-0873. Epub 2017 May 18. Mol Cancer Ther. 2017. PMID: 28522589
9,193 results