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Tropomyosin1 isoforms underlie epithelial to mesenchymal plasticity, metastatic dissemination, and resistance to chemotherapy in high-grade serous ovarian cancer.
Xu T, Verhagen MP, Teeuwssen M, Sun W, Joosten R, Sacchetti A, Ewing-Graham PC, Jansen MPHM, Boere IA, Bryce NS, Zeng J, Treutlein HR, Hook J, Hardeman EC, Gunning PW, Fodde R. Xu T, et al. Among authors: hook j. Cell Death Differ. 2024 Mar;31(3):360-377. doi: 10.1038/s41418-024-01267-9. Epub 2024 Feb 16. Cell Death Differ. 2024. PMID: 38365970 Free PMC article.
On-target action of anti-tropomyosin drugs regulates glucose metabolism.
Kee AJ, Chagan J, Chan JY, Bryce NS, Lucas CA, Zeng J, Hook J, Treutlein H, Laybutt DR, Stehn JR, Gunning PW, Hardeman EC. Kee AJ, et al. Among authors: hook j. Sci Rep. 2018 Mar 15;8(1):4604. doi: 10.1038/s41598-018-22946-x. Sci Rep. 2018. PMID: 29545590 Free PMC article.
Identification of Cancer-Targeted Tropomyosin Inhibitors and Their Synergy with Microtubule Drugs.
Currier MA, Stehn JR, Swain A, Chen D, Hook J, Eiffe E, Heaton A, Brown D, Nartker BA, Eaves DW, Kloss N, Treutlein H, Zeng J, Alieva IB, Dugina VB, Hardeman EC, Gunning PW, Cripe TP. Currier MA, et al. Among authors: hook j. Mol Cancer Ther. 2017 Aug;16(8):1555-1565. doi: 10.1158/1535-7163.MCT-16-0873. Epub 2017 May 18. Mol Cancer Ther. 2017. PMID: 28522589
Parallel assembly of actin and tropomyosin, but not myosin II, during de novo actin filament formation in live mice.
Masedunskas A, Appaduray MA, Lucas CA, Lastra Cagigas M, Heydecker M, Holliday M, Meiring JCM, Hook J, Kee A, White M, Thomas P, Zhang Y, Adelstein RS, Meckel T, Böcking T, Weigert R, Bryce NS, Gunning PW, Hardeman EC. Masedunskas A, et al. Among authors: hook j. J Cell Sci. 2018 Mar 19;131(6):jcs212654. doi: 10.1242/jcs.212654. J Cell Sci. 2018. PMID: 29487177 Free PMC article.
Regulation of cell proliferation by ERK and signal-dependent nuclear translocation of ERK is dependent on Tm5NM1-containing actin filaments.
Schevzov G, Kee AJ, Wang B, Sequeira VB, Hook J, Coombes JD, Lucas CA, Stehn JR, Musgrove EA, Cretu A, Assoian R, Fath T, Hanoch T, Seger R, Pleines I, Kile BT, Hardeman EC, Gunning PW. Schevzov G, et al. Among authors: hook j. Mol Biol Cell. 2015 Jul 1;26(13):2475-90. doi: 10.1091/mbc.E14-10-1453. Epub 2015 May 13. Mol Biol Cell. 2015. PMID: 25971798 Free PMC article.
644 results