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Potential of Nucleic Acid Receptor Ligands to Improve Vaccination Efficacy against the Filarial Nematode Litomosoides sigmodontis.
Scheunemann JF, Risch F, Reichwald JJ, Lenz B, Neumann AL, Garbe S, Frohberger SJ, Koschel M, Ajendra J, Rothe M, Latz E, Coch C, Hartmann G, Schumak B, Hoerauf A, Hübner MP. Scheunemann JF, et al. Among authors: koschel m. Vaccines (Basel). 2023 May 10;11(5):966. doi: 10.3390/vaccines11050966. Vaccines (Basel). 2023. PMID: 37243070 Free PMC article.
The efficacy of the benzimidazoles oxfendazole and flubendazole against Litomosoides sigmodontis is dependent on the adaptive and innate immune system.
Risch F, Scheunemann JF, Reichwald JJ, Lenz B, Ehrens A, Gal J, Fercoq F, Koschel M, Fendler M, Hoerauf A, Martin C, Hübner MP. Risch F, et al. Among authors: koschel m. Front Microbiol. 2023 Jun 27;14:1213143. doi: 10.3389/fmicb.2023.1213143. eCollection 2023. Front Microbiol. 2023. PMID: 37440891 Free PMC article.
Combinations of registered drugs reduce treatment times required to deplete Wolbachia in the Litomosoides sigmodontis mouse model.
Specht S, Pfarr KM, Arriens S, Hübner MP, Klarmann-Schulz U, Koschel M, Sternberg S, Martin C, Ford L, Taylor MJ, Hoerauf A. Specht S, et al. Among authors: koschel m. PLoS Negl Trop Dis. 2018 Jan 4;12(1):e0006116. doi: 10.1371/journal.pntd.0006116. eCollection 2018 Jan. PLoS Negl Trop Dis. 2018. PMID: 29300732 Free PMC article.
Corallopyronin A for short-course anti-wolbachial, macrofilaricidal treatment of filarial infections.
Schiefer A, Hübner MP, Krome A, Lämmer C, Ehrens A, Aden T, Koschel M, Neufeld H, Chaverra-Muñoz L, Jansen R, Kehraus S, König GM, Pogorevc D, Müller R, Stadler M, Hüttel S, Hesterkamp T, Wagner K, Pfarr K, Hoerauf A. Schiefer A, et al. Among authors: koschel m. PLoS Negl Trop Dis. 2020 Dec 7;14(12):e0008930. doi: 10.1371/journal.pntd.0008930. eCollection 2020 Dec. PLoS Negl Trop Dis. 2020. PMID: 33284808 Free PMC article.
Filarial nematode phenotypic screening cascade to identify compounds with anti-parasitic activity for drug discovery optimization.
Hawryluk N, Zhiru L, Carlow C, Gokool S, Townson S, Kreiss T, Chojnowski A, Prorok M, Siekierka J, Ehrens A, Koschel M, Lhermitte-Vallarino N, Martin C, Hoerauf A, Hernandez G, Canan S, Khetani V, Zeldis J, Specht S, Hübner MP, Scandale I. Hawryluk N, et al. Among authors: koschel m. Int J Parasitol Drugs Drug Resist. 2022 Aug;19:89-97. doi: 10.1016/j.ijpddr.2022.06.002. Epub 2022 Jun 23. Int J Parasitol Drugs Drug Resist. 2022. PMID: 35834918 Free PMC article.
Oxfendazole mediates macrofilaricidal efficacy against the filarial nematode Litomosoides sigmodontis in vivo and inhibits Onchocerca spec. motility in vitro.
Hübner MP, Martin C, Specht S, Koschel M, Dubben B, Frohberger SJ, Ehrens A, Fendler M, Struever D, Mitre E, Vallarino-Lhermitte N, Gokool S, Lustigman S, Schneider M, Townson S, Hoerauf A, Scandale I. Hübner MP, et al. Among authors: koschel m. PLoS Negl Trop Dis. 2020 Jul 6;14(7):e0008427. doi: 10.1371/journal.pntd.0008427. eCollection 2020 Jul. PLoS Negl Trop Dis. 2020. PMID: 32628671 Free PMC article.
In vivo kinetics of Wolbachia depletion by ABBV-4083 in L. sigmodontis adult worms and microfilariae.
Hübner MP, Koschel M, Struever D, Nikolov V, Frohberger SJ, Ehrens A, Fendler M, Johannes I, von Geldern TW, Marsh K, Turner JD, Taylor MJ, Ward SA, Pfarr K, Kempf DJ, Hoerauf A. Hübner MP, et al. Among authors: koschel m. PLoS Negl Trop Dis. 2019 Aug 5;13(8):e0007636. doi: 10.1371/journal.pntd.0007636. eCollection 2019 Aug. PLoS Negl Trop Dis. 2019. PMID: 31381563 Free PMC article.
In vivo efficacy of the boron-pleuromutilin AN11251 against Wolbachia of the rodent filarial nematode Litomosoides sigmodontis.
Ehrens A, Lunde CS, Jacobs RT, Struever D, Koschel M, Frohberger SJ, Lenz F, Fendler M, Turner JD, Ward SA, Taylor MJ, Freund YR, Stefanakis R, Easom E, Li X, Plattner JJ, Hoerauf A, Hübner MP. Ehrens A, et al. Among authors: koschel m. PLoS Negl Trop Dis. 2020 Jan 27;14(1):e0007957. doi: 10.1371/journal.pntd.0007957. eCollection 2020 Jan. PLoS Negl Trop Dis. 2020. PMID: 31986143 Free PMC article.
29 results