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Page 1
High Shear Stress Reduces ERG Causing Endothelial-Mesenchymal Transition and Pulmonary Arterial Hypertension.
Shinohara T, Moonen JR, Chun YH, Lee-Yow YC, Okamura K, Szafron JM, Kaplan J, Cao A, Wang L, Taylor S, Isobe S, Dong M, Yang W, Guo K, Franco BD, Pacharinsak C, Pisani LJ, Saitoh S, Mitani Y, Marsden AL, Engreitz JM, Körbelin J, Rabinovitch M. Shinohara T, et al. Among authors: mitani y. bioRxiv [Preprint]. 2024 Feb 4:2024.02.02.578526. doi: 10.1101/2024.02.02.578526. bioRxiv. 2024. PMID: 38352544 Free PMC article. Preprint.
Reduced BMPR2 expression induces GM-CSF translation and macrophage recruitment in humans and mice to exacerbate pulmonary hypertension.
Sawada H, Saito T, Nickel NP, Alastalo TP, Glotzbach JP, Chan R, Haghighat L, Fuchs G, Januszyk M, Cao A, Lai YJ, Perez Vde J, Kim YM, Wang L, Chen PI, Spiekerkoetter E, Mitani Y, Gurtner GC, Sarnow P, Rabinovitch M. Sawada H, et al. Among authors: mitani y. J Exp Med. 2014 Feb 10;211(2):263-80. doi: 10.1084/jem.20111741. Epub 2014 Jan 20. J Exp Med. 2014. PMID: 24446489 Free PMC article.
Dexfenfluramine protects against pulmonary hypertension in rats.
Mitani Y, Mutlu A, Russell JC, Brindley DN, DeAlmeida J, Rabinovitch M. Mitani Y, et al. J Appl Physiol (1985). 2002 Nov;93(5):1770-8. doi: 10.1152/japplphysiol.00500.2002. J Appl Physiol (1985). 2002. PMID: 12381765 Free article.
Macitentan reverses early obstructive pulmonary vasculopathy in rats: early intervention in overcoming the survivin-mediated resistance to apoptosis.
Shinohara T, Sawada H, Otsuki S, Yodoya N, Kato T, Ohashi H, Zhang E, Saitoh S, Shimpo H, Maruyama K, Komada Y, Mitani Y. Shinohara T, et al. Among authors: mitani y. Am J Physiol Lung Cell Mol Physiol. 2015 Mar 15;308(6):L523-38. doi: 10.1152/ajplung.00129.2014. Epub 2014 Dec 24. Am J Physiol Lung Cell Mol Physiol. 2015. PMID: 25539851 Free article.
Perinatal hypoxia aggravates occlusive pulmonary vasculopathy in SU5416/hypoxia-treated rats later in life.
Oshita H, Sawada H, Mitani Y, Tsuboya N, Kabwe JC, Maruyama J, Yusuf A, Ito H, Okamoto R, Otsuki S, Yodoya N, Ohashi H, Oya K, Kobayashi Y, Kobayashi I, Dohi K, Nishimura Y, Saitoh S, Maruyama K, Hirayama M. Oshita H, et al. Among authors: mitani y. Am J Physiol Lung Cell Mol Physiol. 2022 Aug 1;323(2):L178-L192. doi: 10.1152/ajplung.00422.2021. Epub 2022 Jun 28. Am J Physiol Lung Cell Mol Physiol. 2022. PMID: 35762603 Free article.
Potential contribution of phenotypically modulated smooth muscle cells and related inflammation in the development of experimental obstructive pulmonary vasculopathy in rats.
Otsuki S, Sawada H, Yodoya N, Shinohara T, Kato T, Ohashi H, Zhang E, Imanaka-Yoshida K, Shimpo H, Maruyama K, Komada Y, Mitani Y. Otsuki S, et al. Among authors: mitani y. PLoS One. 2015 Feb 25;10(2):e0118655. doi: 10.1371/journal.pone.0118655. eCollection 2015. PLoS One. 2015. PMID: 25714834 Free PMC article.
A non-selective endothelin receptor antagonist bosentan modulates kinetics of bone marrow-derived cells in ameliorating pulmonary hypertension in mice.
Kato T, Mitani Y, Masuya M, Maruyama J, Sawada H, Ohashi H, Ikeyama Y, Otsuki S, Yodoya N, Shinohara T, Miyata E, Zhang E, Katayama N, Shimpo H, Maruyama K, Komada Y, Hirayama M. Kato T, et al. Among authors: mitani y. Pulm Circ. 2020 May 14;10(2):2045894020919355. doi: 10.1177/2045894020919355. eCollection 2020 Apr-Jun. Pulm Circ. 2020. PMID: 32489640 Free PMC article.
The ALK-1/SMAD/ATOH8 axis attenuates hypoxic responses and protects against the development of pulmonary arterial hypertension.
Morikawa M, Mitani Y, Holmborn K, Kato T, Koinuma D, Maruyama J, Vasilaki E, Sawada H, Kobayashi M, Ozawa T, Morishita Y, Bessho Y, Maeda S, Ledin J, Aburatani H, Kageyama R, Maruyama K, Heldin CH, Miyazono K. Morikawa M, et al. Among authors: mitani y. Sci Signal. 2019 Nov 12;12(607):eaay4430. doi: 10.1126/scisignal.aay4430. Sci Signal. 2019. PMID: 31719172 Free PMC article.
CRISPR-mediated Bmpr2 point mutation exacerbates late pulmonary vasculopathy and reduces survival in rats with experimental pulmonary hypertension.
Kabwe JC, Sawada H, Mitani Y, Oshita H, Tsuboya N, Zhang E, Maruyama J, Miyasaka Y, Ko H, Oya K, Ito H, Yodoya N, Otsuki S, Ohashi H, Okamoto R, Dohi K, Nishimura Y, Mashimo T, Hirayama M, Maruyama K. Kabwe JC, et al. Among authors: mitani y. Respir Res. 2022 Apr 8;23(1):87. doi: 10.1186/s12931-022-02005-w. Respir Res. 2022. PMID: 35395852 Free PMC article.
508 results