Reynolds KA - Search Results

1

A continuous epistasis model for predicting growth rate given combinatorial variation in gene expression and environment.

Otto RM, Turska-Nowak A, Brown PM, Reynolds KA. Otto RM, et al. Among authors: reynolds ka. Cell Syst. 2024 Feb 21;15(2):134-148.e7. doi: 10.1016/j.cels.2024.01.003. Epub 2024 Feb 9. Cell Syst. 2024. PMID: 38340730

2

A simplified strategy for titrating gene expression reveals new relationships between genotype, environment, and bacterial growth.

Mathis AD, Otto RM, Reynolds KA. Mathis AD, et al. Among authors: reynolds ka. Nucleic Acids Res. 2021 Jan 11;49(1):e6. doi: 10.1093/nar/gkaa1073. Nucleic Acids Res. 2021. PMID: 33221881 Free PMC article.

3

Hot spots for allosteric regulation on protein surfaces.

Reynolds KA, McLaughlin RN, Ranganathan R. Reynolds KA, et al. Cell. 2011 Dec 23;147(7):1564-75. doi: 10.1016/j.cell.2011.10.049. Cell. 2011. PMID: 22196731 Free PMC article.

4

Finding a common path: predicting gene function using inferred evolutionary trees.

Reynolds KA. Reynolds KA. Dev Cell. 2014 Jul 14;30(1):4-5. doi: 10.1016/j.devcel.2014.06.029. Dev Cell. 2014. PMID: 25026031 Free article.

5

A Two-Enzyme Adaptive Unit within Bacterial Folate Metabolism.

Schober AF, Mathis AD, Ingle C, Park JO, Chen L, Rabinowitz JD, Junier I, Rivoire O, Reynolds KA. Schober AF, et al. Among authors: reynolds ka. Cell Rep. 2019 Jun 11;27(11):3359-3370.e7. doi: 10.1016/j.celrep.2019.05.030. Cell Rep. 2019. PMID: 31189117 Free PMC article.

6

The genetic landscape of a metabolic interaction.

Nguyen TN, Ingle C, Thompson S, Reynolds KA. Nguyen TN, et al. Among authors: reynolds ka. Nat Commun. 2024 Apr 18;15(1):3351. doi: 10.1038/s41467-024-47671-0. Nat Commun. 2024. PMID: 38637543 Free PMC article.

7

High-Order Epistasis in Catalytic Power of Dihydrofolate Reductase Gives Rise to a Rugged Fitness Landscape in the Presence of Trimethoprim Selection.

Tamer YT, Gaszek IK, Abdizadeh H, Batur TA, Reynolds KA, Atilgan AR, Atilgan C, Toprak E. Tamer YT, et al. Among authors: reynolds ka. Mol Biol Evol. 2019 Jul 1;36(7):1533-1550. doi: 10.1093/molbev/msz086. Mol Biol Evol. 2019. PMID: 30982891 Free PMC article.

8

The Genetic Landscape of a Metabolic Interaction.

Nguyen TN, Ingle C, Thompson S, Reynolds KA. Nguyen TN, et al. Among authors: reynolds ka. bioRxiv [Preprint]. 2023 Aug 17:2023.05.28.542639. doi: 10.1101/2023.05.28.542639. bioRxiv. 2023. PMID: 37645784 Free PMC article. Updated. Preprint.

9

Evolution-based design of proteins.

Reynolds KA, Russ WP, Socolich M, Ranganathan R. Reynolds KA, et al. Methods Enzymol. 2013;523:213-35. doi: 10.1016/B978-0-12-394292-0.00010-2. Methods Enzymol. 2013. PMID: 23422432

10

Altered expression of a quality control protease in E. coli reshapes the in vivo mutational landscape of a model enzyme.

Thompson S, Zhang Y, Ingle C, Reynolds KA, Kortemme T. Thompson S, et al. Among authors: reynolds ka. Elife. 2020 Jul 23;9:e53476. doi: 10.7554/eLife.53476. Elife. 2020. PMID: 32701056 Free PMC article.

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