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Discovering selective antiferroptotic inhibitors of the 15LOX/PEBP1 complex noninterfering with biosynthesis of lipid mediators.
Dar HH, Mikulska-Ruminska K, Tyurina YY, Luci DK, Yasgar A, Samovich SN, Kapralov AA, Souryavong AB, Tyurin VA, Amoscato AA, Epperly MW, Shurin GV, Standley M, Holman TR, St Croix CM, Watkins SC, VanDemark AP, Rana S, Zakharov AV, Simeonov A, Marugan J, Mallampalli RK, Wenzel SE, Greenberger JS, Rai G, Bayir H, Bahar I, Kagan VE. Dar HH, et al. Among authors: mallampalli rk. Proc Natl Acad Sci U S A. 2023 Jun 20;120(25):e2218896120. doi: 10.1073/pnas.2218896120. Epub 2023 Jun 16. Proc Natl Acad Sci U S A. 2023. PMID: 37327313 Free PMC article.
Distinct Patterns of SARS-CoV-2 BA.2.87.1 and JN.1 Variants in Immune Evasion, Antigenicity and Cell-Cell Fusion.
Li P, Liu Y, Faraone J, Hsu CC, Chamblee M, Zheng YM, Carlin C, Bednash JS, Horowitz JC, Mallampalli RK, Saif LJ, Oltz EM, Jones D, Li J, Gumina RJ, Liu SL. Li P, et al. Among authors: mallampalli rk. bioRxiv [Preprint]. 2024 Mar 11:2024.03.11.583978. doi: 10.1101/2024.03.11.583978. bioRxiv. 2024. PMID: 38559216 Free PMC article. Updated. Preprint.
STAT1 Employs Myeloid Cell-Extrinsic Mechanisms to Regulate the Neutrophil Response and Provide Protection against Invasive Klebsiella pneumoniae Lung Infection.
Gonzalez-Ferrer S, Peñaloza HF, van der Geest R, Xiong Z, Gheware A, Tabary M, Kochin M, Dalton K, Zou H, Lou D, Lockwood K, Zhang Y, Bain WG, Mallampalli RK, Ray A, Ray P, Van Tyne D, Chen K, Lee JS. Gonzalez-Ferrer S, et al. Among authors: mallampalli rk. Immunohorizons. 2024 Jan 1;8(1):122-135. doi: 10.4049/immunohorizons.2300104. Immunohorizons. 2024. PMID: 38289252 Free PMC article.
Strikingly High Activity of 15-Lipoxygenase Towards Di-Polyunsaturated Arachidonoyl/Adrenoyl-Phosphatidylethanolamines Generates Peroxidation Signals of Ferroptotic Cell Death.
Samovich SN, Mikulska-Ruminska K, Dar HH, Tyurina YY, Tyurin VA, Souryavong AB, Kapralov AA, Amoscato AA, Beharier O, Karumanchi SA, St Croix CM, Yang X, Holman TR, VanDemark AP, Sadovsky Y, Mallampalli RK, Wenzel SE, Gu W, Bunimovich YL, Bahar I, Kagan VE, Bayir H. Samovich SN, et al. Among authors: mallampalli rk. Angew Chem Int Ed Engl. 2024 Feb 26;63(9):e202314710. doi: 10.1002/anie.202314710. Epub 2024 Jan 17. Angew Chem Int Ed Engl. 2024. PMID: 38230815
Immune evasion, infectivity, and fusogenicity of SARS-CoV-2 BA.2.86 and FLip variants.
Qu P, Xu K, Faraone JN, Goodarzi N, Zheng YM, Carlin C, Bednash JS, Horowitz JC, Mallampalli RK, Saif LJ, Oltz EM, Jones D, Gumina RJ, Liu SL. Qu P, et al. Among authors: mallampalli rk. Cell. 2024 Feb 1;187(3):585-595.e6. doi: 10.1016/j.cell.2023.12.026. Epub 2024 Jan 8. Cell. 2024. PMID: 38194968 Free PMC article.
RAB7 deficiency impairs pulmonary artery endothelial function and promotes pulmonary hypertension.
Piper B, Bogamuwa S, Hossain T, Farkas D, Rosas L, Green AC, Newcomb G, Sun N, Ovando-Ricardez JA, Horowitz JC, Bhagwani AR, Yang H, Kudryashova TV, Rojas M, Mora AL, Yan P, Mallampalli RK, Goncharova EA, Eckmann DM, Farkas L. Piper B, et al. Among authors: mallampalli rk. J Clin Invest. 2024 Feb 1;134(3):e169441. doi: 10.1172/JCI169441. J Clin Invest. 2024. PMID: 38015641 Free PMC article.
185 results