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Microsecond dynamics control the HIV-1 Envelope conformation.
Bennett AL, Edwards R, Kosheleva I, Saunders C, Bililign Y, Williams A, Bubphamala P, Manosouri K, Anasti K, Saunders KO, Alam SM, Haynes BF, Acharya P, Henderson R. Bennett AL, et al. Among authors: haynes bf. Sci Adv. 2024 Feb 2;10(5):eadj0396. doi: 10.1126/sciadv.adj0396. Epub 2024 Feb 2. Sci Adv. 2024. PMID: 38306419 Free PMC article.
Disruption of the HIV-1 Envelope allosteric network blocks CD4-induced rearrangements.
Henderson R, Lu M, Zhou Y, Mu Z, Parks R, Han Q, Hsu AL, Carter E, Blanchard SC, Edwards RJ, Wiehe K, Saunders KO, Borgnia MJ, Bartesaghi A, Mothes W, Haynes BF, Acharya P, Munir Alam S. Henderson R, et al. Among authors: haynes bf. Nat Commun. 2020 Jan 24;11(1):520. doi: 10.1038/s41467-019-14196-w. Nat Commun. 2020. PMID: 31980614 Free PMC article.
Difficult-to-neutralize global HIV-1 isolates are neutralized by antibodies targeting open envelope conformations.
Han Q, Jones JA, Nicely NI, Reed RK, Shen X, Mansouri K, Louder M, Trama AM, Alam SM, Edwards RJ, Bonsignori M, Tomaras GD, Korber B, Montefiori DC, Mascola JR, Seaman MS, Haynes BF, Saunders KO. Han Q, et al. Among authors: haynes bf. Nat Commun. 2019 Jul 1;10(1):2898. doi: 10.1038/s41467-019-10899-2. Nat Commun. 2019. PMID: 31263112 Free PMC article.
Neutralization-guided design of HIV-1 envelope trimers with high affinity for the unmutated common ancestor of CH235 lineage CD4bs broadly neutralizing antibodies.
LaBranche CC, Henderson R, Hsu A, Behrens S, Chen X, Zhou T, Wiehe K, Saunders KO, Alam SM, Bonsignori M, Borgnia MJ, Sattentau QJ, Eaton A, Greene K, Gao H, Liao HX, Williams WB, Peacock J, Tang H, Perez LG, Edwards RJ, Kepler TB, Korber BT, Kwong PD, Mascola JR, Acharya P, Haynes BF, Montefiori DC. LaBranche CC, et al. Among authors: haynes bf. PLoS Pathog. 2019 Sep 17;15(9):e1008026. doi: 10.1371/journal.ppat.1008026. eCollection 2019 Sep. PLoS Pathog. 2019. PMID: 31527908 Free PMC article.
Cooperation between somatic mutation and germline-encoded residues enables antibody recognition of HIV-1 envelope glycans.
Wu NR, Nicely NI, Lee EM, Reed RK, Watts BE, Cai F, Walkowicz WE, Aussedat B, Jones JA, Eaton A, Trama AM, Alam SM, Montefiori DC, Haynes BF, Saunders KO. Wu NR, et al. Among authors: haynes bf. PLoS Pathog. 2019 Dec 16;15(12):e1008165. doi: 10.1371/journal.ppat.1008165. eCollection 2019 Dec. PLoS Pathog. 2019. PMID: 31841553 Free PMC article.
Controlling the SARS-CoV-2 Spike Glycoprotein Conformation.
Henderson R, Edwards RJ, Mansouri K, Janowska K, Stalls V, Gobeil S, Kopp M, Hsu A, Borgnia M, Parks R, Haynes BF, Acharya P. Henderson R, et al. Among authors: haynes bf. bioRxiv [Preprint]. 2020 May 18:2020.05.18.102087. doi: 10.1101/2020.05.18.102087. bioRxiv. 2020. PMID: 32511343 Free PMC article. Updated. Preprint.
771 results