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N-Aryl Mercaptopropionamides as Broad-Spectrum Inhibitors of Metallo-β-Lactamases.
Kaya C, Konstantinović J, Kany AM, Andreas A, Kramer JS, Brunst S, Weizel L, Rotter MJ, Frank D, Yahiaoui S, Müller R, Hartmann RW, Haupenthal J, Proschak E, Wichelhaus TA, Hirsch AKH. Kaya C, et al. Among authors: haupenthal j. J Med Chem. 2022 Mar 10;65(5):3913-3922. doi: 10.1021/acs.jmedchem.1c01755. Epub 2022 Feb 21. J Med Chem. 2022. PMID: 35188771
N-Aryl-3-mercaptosuccinimides as Antivirulence Agents Targeting Pseudomonas aeruginosa Elastase and Clostridium Collagenases.
Konstantinović J, Yahiaoui S, Alhayek A, Haupenthal J, Schönauer E, Andreas A, Kany AM, Müller R, Koehnke J, Berger FK, Bischoff M, Hartmann RW, Brandstetter H, Hirsch AKH. Konstantinović J, et al. Among authors: haupenthal j. J Med Chem. 2020 Aug 13;63(15):8359-8368. doi: 10.1021/acs.jmedchem.0c00584. Epub 2020 Jun 17. J Med Chem. 2020. PMID: 32470298 Free PMC article.
Assessment of the rules related to gaining activity against Gram-negative bacteria.
Ropponen HK, Diamanti E, Siemens A, Illarionov B, Haupenthal J, Fischer M, Rottmann M, Witschel M, Hirsch AKH. Ropponen HK, et al. Among authors: haupenthal j. RSC Med Chem. 2021 Mar 3;12(4):593-601. doi: 10.1039/d0md00409j. eCollection 2021 Apr 28. RSC Med Chem. 2021. PMID: 34046630 Free PMC article.
N-Aryl mercaptoacetamides as potential multi-target inhibitors of metallo-β-lactamases (MBLs) and the virulence factor LasB from Pseudomonas aeruginosa.
Yahiaoui S, Voos K, Haupenthal J, Wichelhaus TA, Frank D, Weizel L, Rotter M, Brunst S, Kramer JS, Proschak E, Ducho C, Hirsch AKH. Yahiaoui S, et al. Among authors: haupenthal j. RSC Med Chem. 2021 Jul 29;12(10):1698-1708. doi: 10.1039/d1md00187f. eCollection 2021 Oct 20. RSC Med Chem. 2021. PMID: 34778771 Free PMC article.
63 results