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Discovery of a Macrocyclic Influenza Cap-Dependent Endonuclease Inhibitor.
Feng J, Guo F, Li P, Zhang J, Jiang K, Zhu Z, Yin S, Lin X, Lin F, Xiao F, Xue X, He H, Chen S. Feng J, et al. Among authors: lin f, lin x. J Med Chem. 2024 Feb 22;67(4):2570-2583. doi: 10.1021/acs.jmedchem.3c01715. Epub 2024 Feb 1. J Med Chem. 2024. PMID: 38301207
Discovery of Potent EV71 Capsid Inhibitors for Treatment of HFMD.
Li P, Yu J, Hao F, He H, Shi X, Hu J, Wang L, Du C, Zhang X, Sun Y, Lin F, Gu Z, Xu D, Chen X, Shen L, Hu G, Li J, Chen S, Xiao W, Wang Z, Guo Q, Chang X, Tian X, Lin T. Li P, et al. Among authors: lin f, lin t. ACS Med Chem Lett. 2017 Jul 10;8(8):841-846. doi: 10.1021/acsmedchemlett.7b00188. eCollection 2017 Aug 10. ACS Med Chem Lett. 2017. PMID: 28835799 Free PMC article.
Design, synthesis, and evaluation of a novel macrocyclic anti-EV71 agent.
Li P, Wu S, Xiao T, Li Y, Su Z, Wei W, Hao F, Hu G, Lin F, Chen X, Gu Z, Lin T, He H, Li J, Chen S. Li P, et al. Among authors: lin f, lin t. Bioorg Med Chem. 2020 Jun 15;28(12):115551. doi: 10.1016/j.bmc.2020.115551. Epub 2020 May 8. Bioorg Med Chem. 2020. PMID: 32503695
Structure-activity relationship study of a series of caspase inhibitors containing γ-amino acid moiety for treatment of cholestatic liver disease.
Mou J, Wu S, Luo Z, Guo F, He H, Wang J, Lin F, Guo F, Sun J, Shen L, Zeng M, Wang C, Xu D, Gu Z, Tian X, Zhang A, Xu H, Yang L, Zhang X, Li J, Chen S. Mou J, et al. Among authors: lin f. Bioorg Med Chem Lett. 2018 Jun 1;28(10):1874-1878. doi: 10.1016/j.bmcl.2018.04.002. Epub 2018 Apr 4. Bioorg Med Chem Lett. 2018. PMID: 29650287
Correction to "The Discovery of 3,3'-Spiro[azetidine]-2-oxo-indoline Derivatives as Fusion Inhibitors for Treatment of RSV Infection".
Shi W, Jiang Z, He H, Xiao F, Lin F, Sun Y, Hou L, Shen L, Han L, Zeng M, Lai K, Gu Z, Chen X, Zhao T, Guo L, Yang C, Li J, Chen S. Shi W, et al. Among authors: lin f. ACS Med Chem Lett. 2018 Mar 30;9(4):397. doi: 10.1021/acsmedchemlett.8b00139. eCollection 2018 Apr 12. ACS Med Chem Lett. 2018. PMID: 29671838 Free PMC article.
Inhibition of the hERG potassium ion channel by different non-nucleoside human cytomegalovirus polymerase antiviral inhibitor series and the exploration of variations on a pyrroloquinoline core to reduce cardiotoxicity potential.
Srinivas Kandadai A, Bai B, Rahim M, Lin F, Gu Z, Qi X, Zhang X, Dong H, Chen Y, Shen J, Nieman JA. Srinivas Kandadai A, et al. Among authors: lin f. Bioorg Med Chem. 2023 May 1;85:117276. doi: 10.1016/j.bmc.2023.117276. Epub 2023 Apr 5. Bioorg Med Chem. 2023. PMID: 37037115
Peptidomimetic α-Acyloxymethylketone Warheads with Six-Membered Lactam P1 Glutamine Mimic: SARS-CoV-2 3CL Protease Inhibition, Coronavirus Antiviral Activity, and in Vitro Biological Stability.
Bai B, Belovodskiy A, Hena M, Kandadai AS, Joyce MA, Saffran HA, Shields JA, Khan MB, Arutyunova E, Lu J, Bajwa SK, Hockman D, Fischer C, Lamer T, Vuong W, van Belkum MJ, Gu Z, Lin F, Du Y, Xu J, Rahim M, Young HS, Vederas JC, Tyrrell DL, Lemieux MJ, Nieman JA. Bai B, et al. Among authors: lin f. J Med Chem. 2022 Feb 24;65(4):2905-2925. doi: 10.1021/acs.jmedchem.1c00616. Epub 2021 Jul 9. J Med Chem. 2022. PMID: 34242027
Me-LLaMA: Foundation Large Language Models for Medical Applications.
Xie Q, Chen Q, Chen A, Peng C, Hu Y, Lin F, Peng X, Huang J, Zhang J, Keloth V, Zhou X, He H, Ohno-Machado L, Wu Y, Xu H, Bian J. Xie Q, et al. Among authors: lin f. Res Sq [Preprint]. 2024 May 22:rs.3.rs-4240043. doi: 10.21203/rs.3.rs-4240043/v1. Res Sq. 2024. PMID: 38826372 Free PMC article. Preprint.
9,463 results