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Kinase-impaired BTK mutations are susceptible to clinical-stage BTK and IKZF1/3 degrader NX-2127.
Montoya S, Bourcier J, Noviski M, Lu H, Thompson MC, Chirino A, Jahn J, Sondhi AK, Gajewski S, Tan YSM, Yung S, Urban A, Wang E, Han C, Mi X, Kim WJ, Sievers Q, Auger P, Bousquet H, Brathaban N, Bravo B, Gessner M, Guiducci C, Iuliano JN, Kane T, Mukerji R, Reddy PJ, Powers J, Sanchez Garcia de Los Rios M, Ye J, Barrientos Risso C, Tsai D, Pardo G, Notti RQ, Pardo A, Affer M, Nawaratne V, Totiger TM, Pena-Velasquez C, Rhodes JM, Zelenetz AD, Alencar A, Roeker LE, Mehta S, Garippa R, Linley A, Soni RK, Skånland SS, Brown RJ, Mato AR, Hansen GM, Abdel-Wahab O, Taylor J. Montoya S, et al. Among authors: ye j. Science. 2024 Feb 2;383(6682):eadi5798. doi: 10.1126/science.adi5798. Epub 2024 Feb 2. Science. 2024. PMID: 38301010 Free PMC article.
Discovery and Preclinical Pharmacology of NX-2127, an Orally Bioavailable Degrader of Bruton's Tyrosine Kinase with Immunomodulatory Activity for the Treatment of Patients with B Cell Malignancies.
Robbins DW, Noviski MA, Tan YS, Konst ZA, Kelly A, Auger P, Brathaban N, Cass R, Chan ML, Cherala G, Clifton MC, Gajewski S, Ingallinera TG, Karr D, Kato D, Ma J, McKinnell J, McIntosh J, Mihalic J, Murphy B, Panga JR, Peng G, Powers J, Perez L, Rountree R, Tenn-McClellan A, Sands AT, Weiss DR, Wu J, Ye J, Guiducci C, Hansen G, Cohen F. Robbins DW, et al. Among authors: ye j. J Med Chem. 2024 Feb 22;67(4):2321-2336. doi: 10.1021/acs.jmedchem.3c01007. Epub 2024 Feb 1. J Med Chem. 2024. PMID: 38300987
NBR1 enables autophagy-dependent focal adhesion turnover.
Kenific CM, Stehbens SJ, Goldsmith J, Leidal AM, Faure N, Ye J, Wittmann T, Debnath J. Kenific CM, et al. Among authors: ye j. J Cell Biol. 2016 Feb 29;212(5):577-90. doi: 10.1083/jcb.201503075. Epub 2016 Feb 22. J Cell Biol. 2016. PMID: 26903539 Free PMC article.
A computationally engineered RAS rheostat reveals RAS-ERK signaling dynamics.
Rose JC, Huang PS, Camp ND, Ye J, Leidal AM, Goreshnik I, Trevillian BM, Dickinson MS, Cunningham-Bryant D, Debnath J, Baker D, Wolf-Yadlin A, Maly DJ. Rose JC, et al. Among authors: ye j. Nat Chem Biol. 2017 Jan;13(1):119-126. doi: 10.1038/nchembio.2244. Epub 2016 Nov 21. Nat Chem Biol. 2017. PMID: 27870838 Free PMC article.
Coping with alpine habitats: genomic insights into the adaptation strategies of Triplostegia glandulifera (Caprifoliaceae).
Zhang J, Dong KL, Ren MZ, Wang ZW, Li JH, Sun WJ, Zhao X, Fu XX, Ye JF, Liu B, Zhang DM, Wang MZ, Zeng G, Niu YT, Lu LM, Su JX, Liu ZJ, Soltis PS, Soltis DE, Chen ZD. Zhang J, et al. Among authors: ye jf. Hortic Res. 2024 May 1;11(5):uhae077. doi: 10.1093/hr/uhae077. eCollection 2024 May. Hortic Res. 2024. PMID: 38779140 Free PMC article.
SERSomes for metabolic phenotyping and prostate cancer diagnosis.
Bi X, Wang J, Xue B, He C, Liu F, Chen H, Lin LL, Dong B, Li B, Jin C, Pan J, Xue W, Ye J. Bi X, et al. Among authors: ye j. Cell Rep Med. 2024 May 14:101579. doi: 10.1016/j.xcrm.2024.101579. Online ahead of print. Cell Rep Med. 2024. PMID: 38776910
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