Eck MJ - Search Results

1

ZNL0325, a Pyrazolopyrimidine-Based Covalent Probe, Demonstrates an Alternative Binding Mode for Kinases.

Li Z, Lu W, Beyett TS, Ficarro SB, Jiang J, Tse J, Kim AY, Marto JA, Che J, Jänne PA, Eck MJ, Zhang T, Gray NS. Li Z, et al. Among authors: eck mj. J Med Chem. 2024 Feb 22;67(4):2837-2848. doi: 10.1021/acs.jmedchem.3c01891. Epub 2024 Feb 1. J Med Chem. 2024. PMID: 38300264

2

A Constitutive EGFR Kinase Dimer to Study Inhibitor Pharmacology.

Kim JJ, Schaeffner IK, Heppner DE, To C, Jänne PA, Beyett TS, Eck MJ. Kim JJ, et al. Among authors: eck mj. Mol Pharmacol. 2024 Jan 10;105(2):97-103. doi: 10.1124/molpharm.123.000768. Mol Pharmacol. 2024. PMID: 38164587

3

Structural Analysis of the Macrocyclic Inhibitor BI-4020 Binding to EGFR Kinase.

Beyett TS, Rana JK, Schaeffner IK, Heppner DE, Eck MJ. Beyett TS, et al. Among authors: eck mj. ChemMedChem. 2024 Mar 24:e202300343. doi: 10.1002/cmdc.202300343. Online ahead of print. ChemMedChem. 2024. PMID: 38523074

4

Signaling from RAS to RAF: The Molecules and Their Mechanisms.

Jeon H, Tkacik E, Eck MJ. Jeon H, et al. Among authors: eck mj. Annu Rev Biochem. 2024 Feb 5. doi: 10.1146/annurev-biochem-052521-040754. Online ahead of print. Annu Rev Biochem. 2024. PMID: 38316136 Review.

5

Linking ATP and allosteric sites to achieve superadditive binding with bivalent EGFR kinase inhibitors.

Wittlinger F, Ogboo BC, Shevchenko E, Damghani T, Pham CD, Schaeffner IK, Oligny BT, Chitnis SP, Beyett TS, Rasch A, Buckley B, Urul DA, Shaurova T, May EW, Schaefer EM, Eck MJ, Hershberger PA, Poso A, Laufer SA, Heppner DE. Wittlinger F, et al. Among authors: eck mj. Commun Chem. 2024 Feb 20;7(1):38. doi: 10.1038/s42004-024-01108-3. Commun Chem. 2024. PMID: 38378740 Free PMC article.

6

Publisher Correction: Cryo-EM structure of a RAS/RAF recruitment complex.

Park E, Rawson S, Schmoker A, Kim BW, Oh S, Song K, Jeon H, Eck MJ. Park E, et al. Among authors: eck mj. Nat Commun. 2023 Sep 7;14(1):5517. doi: 10.1038/s41467-023-41365-9. Nat Commun. 2023. PMID: 37679375 Free PMC article. No abstract available.

7

Cryo-EM structure of a RAS/RAF recruitment complex.

Park E, Rawson S, Schmoker A, Kim BW, Oh S, Song K, Jeon H, Eck MJ. Park E, et al. Among authors: eck mj. Nat Commun. 2023 Jul 29;14(1):4580. doi: 10.1038/s41467-023-40299-6. Nat Commun. 2023. PMID: 37516774 Free PMC article.

8

Oncogenic K-Ras suppresses global miRNA function.

Shui B, Beyett TS, Chen Z, Li X, La Rocca G, Gazlay WM, Eck MJ, Lau KS, Ventura A, Haigis KM. Shui B, et al. Among authors: eck mj. Mol Cell. 2023 Jul 20;83(14):2509-2523.e13. doi: 10.1016/j.molcel.2023.06.008. Epub 2023 Jul 3. Mol Cell. 2023. PMID: 37402366

9

Structural elements that enable specificity for mutant EGFR kinase domains with next-generation small-molecule inhibitors.

Damghani T, Wittlinger F, Beyett TS, Eck MJ, Laufer SA, Heppner DE. Damghani T, et al. Among authors: eck mj. Methods Enzymol. 2023;685:171-198. doi: 10.1016/bs.mie.2023.03.013. Epub 2023 Apr 27. Methods Enzymol. 2023. PMID: 37245901 Free PMC article.

10

Structure and RAF family kinase isoform selectivity of type II RAF inhibitors tovorafenib and naporafenib.

Tkacik E, Li K, Gonzalez-Del Pino G, Ha BH, Vinals J, Park E, Beyett TS, Eck MJ. Tkacik E, et al. Among authors: eck mj. J Biol Chem. 2023 May;299(5):104634. doi: 10.1016/j.jbc.2023.104634. Epub 2023 Mar 22. J Biol Chem. 2023. PMID: 36963492 Free PMC article.

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