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Synthesis, Molecular Docking and Biological Characterization of Pyrazine Linked 2-Aminobenzamides as New Class I Selective Histone Deacetylase (HDAC) Inhibitors with Anti-Leukemic Activity.
Ibrahim HS, Abdelsalam M, Zeyn Y, Zessin M, Mustafa AM, Fischer MA, Zeyen P, Sun P, Bülbül EF, Vecchio A, Erdmann F, Schmidt M, Robaa D, Barinka C, Romier C, Schutkowski M, Krämer OH, Sippl W. Ibrahim HS, et al. Among authors: barinka c. Int J Mol Sci. 2021 Dec 29;23(1):369. doi: 10.3390/ijms23010369. Int J Mol Sci. 2021. PMID: 35008795 Free PMC article.
Continuous Activity Assay for HDAC11 Enabling Reevaluation of HDAC Inhibitors.
Kutil Z, Mikešová J, Zessin M, Meleshin M, Nováková Z, Alquicer G, Kozikowski A, Sippl W, Bařinka C, Schutkowski M. Kutil Z, et al. Among authors: barinka c. ACS Omega. 2019 Nov 15;4(22):19895-19904. doi: 10.1021/acsomega.9b02808. eCollection 2019 Nov 26. ACS Omega. 2019. PMID: 31788622 Free PMC article.
Continuous Sirtuin/HDAC (histone deacetylase) activity assay using thioamides as PET (Photoinduced Electron Transfer)-based fluorescence quencher.
Zessin M, Meleshin M, Simic Z, Kalbas D, Arbach M, Gebhardt P, Melesina J, Liebscher S, Bordusa F, Sippl W, Barinka C, Schutkowski M. Zessin M, et al. Among authors: barinka c. Bioorg Chem. 2021 Dec;117:105425. doi: 10.1016/j.bioorg.2021.105425. Epub 2021 Oct 12. Bioorg Chem. 2021. PMID: 34695733 Free article.
Histone Deacetylase 11 Is a Fatty-Acid Deacylase.
Kutil Z, Novakova Z, Meleshin M, Mikesova J, Schutkowski M, Barinka C. Kutil Z, et al. Among authors: barinka c. ACS Chem Biol. 2018 Mar 16;13(3):685-693. doi: 10.1021/acschembio.7b00942. Epub 2018 Jan 30. ACS Chem Biol. 2018. PMID: 29336543
Comprehensive Mechanistic View of the Hydrolysis of Oxadiazole-Based Inhibitors by Histone Deacetylase 6 (HDAC6).
Motlová L, Šnajdr I, Kutil Z, Andris E, Ptáček J, Novotná A, Nováková Z, Havlínová B, Tueckmantel W, Dráberová H, Majer P, Schutkowski M, Kozikowski A, Rulíšek L, Bařinka C. Motlová L, et al. Among authors: barinka c. ACS Chem Biol. 2023 Jul 21;18(7):1594-1610. doi: 10.1021/acschembio.3c00212. Epub 2023 Jul 1. ACS Chem Biol. 2023. PMID: 37392419 Free PMC article.
101 results