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Evaluating the efficacy and safety of pozelimab in patients with CD55 deficiency with hyperactivation of complement, angiopathic thrombosis, and protein-losing enteropathy disease: an open-label phase 2 and 3 study.
Ozen A, Chongsrisawat V, Sefer AP, Kolukisa B, Jalbert JJ, Meagher KA, Brackin T, Feldman HB, Baris S, Karakoc-Aydiner E, Ergelen R, Fuss IJ, Moorman H, Suratannon N, Suphapeetiporn K, Perlee L, Harari OA, Yancopoulos GD, Lenardo MJ; Pozelimab CHAPLE Working Group. Ozen A, et al. Among authors: meagher ka. Lancet. 2024 Feb 17;403(10427):645-656. doi: 10.1016/S0140-6736(23)02358-9. Epub 2024 Jan 23. Lancet. 2024. PMID: 38278170 Clinical Trial.
Humanized C3 Mouse: A Novel Accelerated Model of C3 Glomerulopathy.
Devalaraja-Narashimha K, Meagher K, Luo Y, Huang C, Kaplan T, Muthuswamy A, Halasz G, Casanova S, O'Brien J, Peyser Boiarsky R, McWhirter J, Gartner H, Bai Y, MacDonnell S, Liu C, Hu Y, Latuszek A, Wei Y, Prasad S, Huang T, Yancopoulos G, Murphy A, Olson W, Zambrowicz B, Macdonald L, Morton LG. Devalaraja-Narashimha K, et al. J Am Soc Nephrol. 2021 Jan;32(1):99-114. doi: 10.1681/ASN.2020050698. Epub 2020 Dec 7. J Am Soc Nephrol. 2021. PMID: 33288630 Free PMC article.
Humanization of T cell-mediated immunity in mice.
Moore MJ, Zhong M, Hansen J, Gartner H, Grant C, Huang M, Harris FM, Tu N, Bowerman NA, Edelmann KH, Barry T, Herbin O, Tay CS, DiLillo DJ, Decker CE, Levenkova N, Shevchuk J, Dhanik A, Meagher KA, Karr A, Roos J, Lee WY, Suh D, Eckersdorff M, Meagher TC, Koss M, Esau L, Sleeman MA, Babb R, Chen G, Kyratsous CA, Poueymirou WT, McWhirter JR, Voronina VA, Guo C, Gurer C, Yancopoulos GD, Murphy AJ, Macdonald LE. Moore MJ, et al. Among authors: meagher ka. Sci Immunol. 2021 Dec 17;6(66):eabj4026. doi: 10.1126/sciimmunol.abj4026. Epub 2021 Dec 17. Sci Immunol. 2021. PMID: 34919442
Kappa-on-Heavy (KoH) bodies are a distinct class of fully-human antibody-like therapeutic agents with antigen-binding properties.
Macdonald LE, Meagher KA, Franklin MC, Levenkova N, Hansen J, Badithe AT, Zhong M, Krueger P, Rafique A, Tu N, Shevchuk J, Wadhwa S, Ehrlich G, Bautista J, Grant C, Esau L, Poueymirou WT, Auerbach W, Morton L, Babb R, Chen G, Huang T, MacDonald D, Graham K, Gurer C, Voronina VA, McWhirter JR, Guo C, Yancopoulos GD, Murphy AJ. Macdonald LE, et al. Among authors: meagher ka. Proc Natl Acad Sci U S A. 2020 Jan 7;117(1):292-299. doi: 10.1073/pnas.1901734117. Epub 2019 Dec 26. Proc Natl Acad Sci U S A. 2020. PMID: 31879340 Free PMC article.
A novel bispecific antibody platform to direct complement activity for efficient lysis of target cells.
Cruz JW, Damko E, Modi B, Tu N, Meagher K, Voronina V, Gartner H, Ehrlich G, Rafique A, Babb R, Aneja P, Potocky TB, D' Orvilliers A, Coppi A, E SY, Qiu H, Williams CM, Bennett BL, Chen G, Macdonald L, Olson W, Lin JC, Stahl N, Murphy AJ, Kyratsous CA, Prasad BC. Cruz JW, et al. Sci Rep. 2019 Aug 19;9(1):12031. doi: 10.1038/s41598-019-48461-1. Sci Rep. 2019. PMID: 31427700 Free PMC article.
Flow Cytometric Characterization of Murine B Cell Development.
Harris FM, Meagher KA, Zhong M, Daniel BJ, Eckersdorff M, Green JA, Voronina V, Guo C, Limnander A, Macdonald LE. Harris FM, et al. Among authors: meagher ka. J Vis Exp. 2021 Jan 22;(167). doi: 10.3791/61565. J Vis Exp. 2021. PMID: 33554965
Verification of Meso-Zeaxanthin in Fish.
Nolan JM, Beatty S, Meagher KA, Howard AN, Kelly D, Thurnham DI. Nolan JM, et al. Among authors: meagher ka. J Food Process Technol. 2014 Jun 1;5(6):335. doi: 10.4172/2157-7110.1000335. J Food Process Technol. 2014. PMID: 25717420 Free PMC article.
14 results