Williams NS - Search Results

1

Short peptides based on the conserved regions of MIEN1 protein exhibit anticancer activity by targeting the MIEN1 signaling pathway.

Tripathi AK, Desai PP, Tyagi A, Lampe JB, Srivastava Y, Donkor M, Jones HP, Dzyuba SV, Crossley E, Williams NS, Vishwanatha JK. Tripathi AK, et al. Among authors: williams ns. J Biol Chem. 2024 Mar;300(3):105680. doi: 10.1016/j.jbc.2024.105680. Epub 2024 Jan 23. J Biol Chem. 2024. PMID: 38272230 Free PMC article.

2

Identification of DNMT1 selective antagonists using a novel scintillation proximity assay.

Kilgore JA, Du X, Melito L, Wei S, Wang C, Chin HG, Posner B, Pradhan S, Ready JM, Williams NS. Kilgore JA, et al. Among authors: williams ns. J Biol Chem. 2013 Jul 5;288(27):19673-84. doi: 10.1074/jbc.M112.443895. Epub 2013 May 13. J Biol Chem. 2013. PMID: 23671287 Free PMC article.

3

The hormonal profile in women using oral contraceptives is not as stable as previously thought: a temporal analysis of serum endogenous and exogenous hormones.

Rodriguez LA 2nd, Casey E, Crossley E, Williams N, Dhaher YY. Rodriguez LA 2nd, et al. Am J Physiol Endocrinol Metab. 2024 May 22. doi: 10.1152/ajpendo.00418.2023. Online ahead of print. Am J Physiol Endocrinol Metab. 2024. PMID: 38775726

4

Structure-guided development of specific pyruvate dehydrogenase kinase inhibitors targeting the ATP-binding pocket.

Tso SC, Qi X, Gui WJ, Wu CY, Chuang JL, Wernstedt-Asterholm I, Morlock LK, Owens KR, Scherer PE, Williams NS, Tambar UK, Wynn RM, Chuang DT. Tso SC, et al. Among authors: williams ns. J Biol Chem. 2014 Feb 14;289(7):4432-43. doi: 10.1074/jbc.M113.533885. Epub 2013 Dec 19. J Biol Chem. 2014. PMID: 24356970 Free PMC article.

5

Targeting QseC signaling and virulence for antibiotic development.

Rasko DA, Moreira CG, Li de R, Reading NC, Ritchie JM, Waldor MK, Williams N, Taussig R, Wei S, Roth M, Hughes DT, Huntley JF, Fina MW, Falck JR, Sperandio V. Rasko DA, et al. Science. 2008 Aug 22;321(5892):1078-80. doi: 10.1126/science.1160354. Science. 2008. PMID: 18719281 Free PMC article.

6

Structure-activity relationship studies of small-molecule inhibitors of Wnt response.

Lu J, Ma Z, Hsieh JC, Fan CW, Chen B, Longgood JC, Williams NS, Amatruda JF, Lum L, Chen C. Lu J, et al. Among authors: williams ns. Bioorg Med Chem Lett. 2009 Jul 15;19(14):3825-7. doi: 10.1016/j.bmcl.2009.04.040. Epub 2009 Apr 18. Bioorg Med Chem Lett. 2009. PMID: 19410457 Free PMC article.

7

The Hedgehog pathway effector smoothened exhibits signaling competency in the absence of ciliary accumulation.

Fan CW, Chen B, Franco I, Lu J, Shi H, Wei S, Wang C, Wu X, Tang W, Roth MG, Williams NS, Hirsch E, Chen C, Lum L. Fan CW, et al. Among authors: williams ns. Chem Biol. 2014 Dec 18;21(12):1680-9. doi: 10.1016/j.chembiol.2014.10.013. Epub 2014 Dec 4. Chem Biol. 2014. PMID: 25484239 Free PMC article.

8

Fungal-Selective Resorcylate Aminopyrazole Hsp90 Inhibitors: Optimization of Whole-Cell Anticryptococcal Activity and Insights into the Structural Origins of Cryptococcal Selectivity.

Marcyk PT, LeBlanc EV, Kuntz DA, Xue A, Ortiz F, Trilles R, Bengtson S, Kenney TMG, Huang DS, Robbins N, Williams NS, Krysan DJ, Privé GG, Whitesell L, Cowen LE, Brown LE. Marcyk PT, et al. Among authors: williams ns. J Med Chem. 2021 Jan 28;64(2):1139-1169. doi: 10.1021/acs.jmedchem.0c01777. Epub 2021 Jan 14. J Med Chem. 2021. PMID: 33444025 Free PMC article.

9

Novel Bcl-2 Inhibitors Selectively Disrupt the Autophagy-Specific Bcl-2-Beclin 1 Protein-Protein Interaction.

Dong X, Liang Q, Pan YZ, Wang X, Kuo YC, Chiang WC, Zhang X, Williams NS, Rizo J, Levine B, De Brabander JK. Dong X, et al. Among authors: williams ns. ACS Med Chem Lett. 2022 Aug 12;13(9):1510-1516. doi: 10.1021/acsmedchemlett.2c00309. eCollection 2022 Sep 8. ACS Med Chem Lett. 2022. PMID: 36105331 Free PMC article.

10

The development of highly potent inhibitors for porcupine.

Wang X, Moon J, Dodge ME, Pan X, Zhang L, Hanson JM, Tuladhar R, Ma Z, Shi H, Williams NS, Amatruda JF, Carroll TJ, Lum L, Chen C. Wang X, et al. Among authors: williams ns. J Med Chem. 2013 Mar 28;56(6):2700-4. doi: 10.1021/jm400159c. Epub 2013 Mar 19. J Med Chem. 2013. PMID: 23477365 Free PMC article.

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