McDonald PR - Search Results

1

Mutation of highly conserved residues in loop 2 of the coronavirus macrodomain demonstrates that enhanced ADP-ribose binding is detrimental to infection.

Kerr CM, Pfannenstiel JJ, Alhammad YM, Roy A, O'Connor JJ, Ghimire R, Khattabi R, Shrestha R, McDonald PR, Gao P, Johnson DK, More S, Channappanavar R, Fehr AR. Kerr CM, et al. Among authors: mcdonald pr. bioRxiv [Preprint]. 2024 Jan 4:2024.01.03.574082. doi: 10.1101/2024.01.03.574082. bioRxiv. 2024. PMID: 38260573 Free PMC article. Preprint.

2

The SARS-CoV-2 conserved macrodomain is a mono-ADP-ribosylhydrolase.

Alhammad YMO, Kashipathy MM, Roy A, Gagné JP, McDonald P, Gao P, Nonfoux L, Battaile KP, Johnson DK, Holmstrom ED, Poirier GG, Lovell S, Fehr AR. Alhammad YMO, et al. bioRxiv [Preprint]. 2020 Oct 28:2020.05.11.089375. doi: 10.1101/2020.05.11.089375. bioRxiv. 2020. PMID: 32511412 Free PMC article. Updated. Preprint.

3

The SARS-CoV-2 Conserved Macrodomain Is a Mono-ADP-Ribosylhydrolase.

Alhammad YMO, Kashipathy MM, Roy A, Gagné JP, McDonald P, Gao P, Nonfoux L, Battaile KP, Johnson DK, Holmstrom ED, Poirier GG, Lovell S, Fehr AR. Alhammad YMO, et al. J Virol. 2021 Jan 13;95(3):e01969-20. doi: 10.1128/JVI.01969-20. Print 2021 Jan 13. J Virol. 2021. PMID: 33158944 Free PMC article.

4

Discovery of compounds that inhibit SARS-CoV-2 Mac1-ADP-ribose binding by high-throughput screening.

Roy A, Alhammad YM, McDonald P, Johnson DK, Zhuo J, Wazir S, Ferraris D, Lehtiö L, Leung AKL, Fehr AR. Roy A, et al. Antiviral Res. 2022 Jul;203:105344. doi: 10.1016/j.antiviral.2022.105344. Epub 2022 May 19. Antiviral Res. 2022. PMID: 35598780 Free PMC article.

5

Simple and rapid high-throughput assay to identify HSV-1 ICP0 transactivation inhibitors.

Ly CY, Yu C, McDonald PR, Roy A, Johnson DK, Davido DJ. Ly CY, et al. Among authors: mcdonald pr. Antiviral Res. 2021 Oct;194:105160. doi: 10.1016/j.antiviral.2021.105160. Epub 2021 Aug 9. Antiviral Res. 2021. PMID: 34384824 Free PMC article.

6

The University of Kansas High-Throughput Screening laboratory. Part I: meeting drug-discovery needs in the heartland of America with entrepreneurial flair.

McDonald PR, Roy A, Chaguturu R. McDonald PR, et al. Future Med Chem. 2011 May;3(7):789-95. doi: 10.4155/fmc.11.36. Future Med Chem. 2011. PMID: 21644824 Free PMC article.

7

The University of Kansas High-Throughput Screening Laboratory. Part II: enabling collaborative drug-discovery partnerships through cutting-edge screening technology.

McDonald PR, Roy A, Chaguturu R. McDonald PR, et al. Future Med Chem. 2011 Jul;3(9):1101-10. doi: 10.4155/fmc.11.84. Future Med Chem. 2011. PMID: 21806374 Free PMC article.

8

Identification and validation of novel small molecule disruptors of HuR-mRNA interaction.

Wu X, Lan L, Wilson DM, Marquez RT, Tsao WC, Gao P, Roy A, Turner BA, McDonald P, Tunge JA, Rogers SA, Dixon DA, Aubé J, Xu L. Wu X, et al. ACS Chem Biol. 2015 Jun 19;10(6):1476-84. doi: 10.1021/cb500851u. Epub 2015 Mar 17. ACS Chem Biol. 2015. PMID: 25750985 Free PMC article.

9

Drug screening to target nuclear orphan receptor NR4A2 for cancer therapeutics.

Komiya T, Yamamoto S, Roy A, McDonald P, Perez RP. Komiya T, et al. Transl Lung Cancer Res. 2017 Oct;6(5):600-610. doi: 10.21037/tlcr.2017.07.02. Transl Lung Cancer Res. 2017. PMID: 29114475 Free PMC article.

10

YM155 Inhibits NleB and SseK Arginine Glycosyltransferase Activity.

Zhu C, El Qaidi S, McDonald P, Roy A, Hardwidge PR. Zhu C, et al. Among authors: mcdonald p. Pathogens. 2021 Feb 23;10(2):253. doi: 10.3390/pathogens10020253. Pathogens. 2021. PMID: 33672424 Free PMC article.

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