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Anti-seizure effects of JNJ-54175446 in the intra-amygdala kainic acid model of drug-resistant temporal lobe epilepsy in mice.
Mamad O, Heiland M, Lindner AU, Hill TDM, Ronroy RM, Rentrup K, Sanz-Rodriguez A, Langa E, Heller JP, Moreno O, Llop J, Bhattacharya A, Palmer JA, Ceusters M, Engel T, Henshall DC. Mamad O, et al. Among authors: langa e. Front Pharmacol. 2024 Jan 8;14:1308478. doi: 10.3389/fphar.2023.1308478. eCollection 2023. Front Pharmacol. 2024. PMID: 38259288 Free PMC article.
Differential microRNA editing may drive target pathway switching in human temporal lobe epilepsy.
Lau KEH, Nguyen NT, Kesavan JC, Langa E, Fanning K, Brennan GP, Sanz-Rodriguez A, Villegas-Salmerón J, Yan Y, Venø MT, Mills JD, Rosenow F, Bauer S, Kjems J, Henshall DC. Lau KEH, et al. Among authors: langa e. Brain Commun. 2024 Jan 3;6(1):fcad355. doi: 10.1093/braincomms/fcad355. eCollection 2024. Brain Commun. 2024. PMID: 38204971 Free PMC article.
Brain cell-specific origin of circulating microRNA biomarkers in experimental temporal lobe epilepsy.
Brindley E, Heiland M, Mooney C, Diviney M, Mamad O, Hill TDM, Yan Y, Venø MT, Reschke CR, Batool A, Langa E, Sanz-Rodriguez A, Heller JP, Morris G, Conboy K, Kjems J, Brennan GP, Henshall DC. Brindley E, et al. Among authors: langa e. Front Mol Neurosci. 2023 Sep 22;16:1230942. doi: 10.3389/fnmol.2023.1230942. eCollection 2023. Front Mol Neurosci. 2023. PMID: 37808470 Free PMC article.
MicroRNA-335-5p suppresses voltage-gated sodium channel expression and may be a target for seizure control.
Heiland M, Connolly NMC, Mamad O, Nguyen NT, Kesavan JC, Langa E, Fanning K, Sanfeliu A, Yan Y, Su J, Venø MT, Costard LS, Neubert V, Engel T, Hill TDM, Freiman TM, Mahesh A, Tiwari VK, Rosenow F, Bauer S, Kjems J, Morris G, Henshall DC. Heiland M, et al. Among authors: langa e. Proc Natl Acad Sci U S A. 2023 Jul 25;120(30):e2216658120. doi: 10.1073/pnas.2216658120. Epub 2023 Jul 18. Proc Natl Acad Sci U S A. 2023. PMID: 37463203 Free PMC article.
44 results