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Effect of the Phosphoryl Guanidine Modification in Chimeric DNA-RNA crRNAs on the Activity of the CRISPR-Cas9 System In Vitro.
ACS Chem Biol. 2024 May 30. doi: 10.1021/acschembio.4c00147. Online ahead of print.
ACS Chem Biol. 2024.
PMID: 38814157
Influence of Combinations of Lipophilic and Phosphate Backbone Modifications on Cellular Uptake of Modified Oligonucleotides.
Zharkov TD, Markov OV, Zhukov SA, Khodyreva SN, Kupryushkin MS.
Zharkov TD, et al.
Molecules. 2024 Jan 17;29(2):452. doi: 10.3390/molecules29020452.
Molecules. 2024.
PMID: 38257365
Free PMC article.
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Back-Up Base Excision DNA Repair in Human Cells Deficient in the Major AP Endonuclease, APE1.
Kim DV, Diatlova EA, Zharkov TD, Melentyev VS, Yudkina AV, Endutkin AV, Zharkov DO.
Kim DV, et al. Among authors: zharkov td.
Int J Mol Sci. 2023 Dec 20;25(1):64. doi: 10.3390/ijms25010064.
Int J Mol Sci. 2023.
PMID: 38203235
Free PMC article.
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Fork- and Comb-like Lipophilic Structures: Different Chemical Approaches to the Synthesis of Oligonucleotides with Multiple Dodecyl Residues.
Zharkov TD, Mironova EM, Markov OV, Zhukov SA, Khodyreva SN, Kupryushkin MS.
Zharkov TD, et al.
Int J Mol Sci. 2023 Sep 27;24(19):14637. doi: 10.3390/ijms241914637.
Int J Mol Sci. 2023.
PMID: 37834092
Free PMC article.
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Complexes and Supramolecular Associates of Dodecyl-Containing Oligonucleotides with Serum Albumin.
Pavlova AS, Ilyushchenko VV, Kupryushkin MS, Zharkov TD, Dyudeeva ES, Bauer IA, Chubarov AS, Pyshnyi DV, Pyshnaya IA.
Pavlova AS, et al. Among authors: zharkov td.
Biochemistry (Mosc). 2023 Aug;88(8):1165-1180. doi: 10.1134/S0006297923080102.
Biochemistry (Mosc). 2023.
PMID: 37758315
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The Lipophilic Purine Nucleoside-Tdp1 Inhibitor-Enhances DNA Damage Induced by Topotecan In Vitro and Potentiates the Antitumor Effect of Topotecan In Vivo.
Chernyshova IA, Zakharenko AL, Kurochkin NN, Dyrkheeva NS, Kornienko TE, Popova NA, Nikolin VP, Ilina ES, Zharkov TD, Kupryushkin MS, Oslovsky VE, Drenichev MS, Lavrik OI.
Chernyshova IA, et al. Among authors: zharkov td.
Molecules. 2022 Dec 31;28(1):323. doi: 10.3390/molecules28010323.
Molecules. 2022.
PMID: 36615517
Free PMC article.
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Recognition of a Clickable Abasic Site Analog by DNA Polymerases and DNA Repair Enzymes.
Endutkin AV, Yudkina AV, Zharkov TD, Kim DV, Zharkov DO.
Endutkin AV, et al. Among authors: zharkov td.
Int J Mol Sci. 2022 Nov 1;23(21):13353. doi: 10.3390/ijms232113353.
Int J Mol Sci. 2022.
PMID: 36362137
Free PMC article.
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