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Molecular mechanism of rhinovirus escape from the Pyrazolo[3,4-d]pyrimidine capsid-binding inhibitor OBR-5-340 via mutations distant from the binding pocket: Derivatives that brake resistance.
Richter M, Döring K, Blaas D, Riabova O, Khrenova M, Kazakova E, Egorova A, Makarov V, Schmidtke M. Richter M, et al. Among authors: schmidtke m. Antiviral Res. 2024 Feb;222:105810. doi: 10.1016/j.antiviral.2024.105810. Epub 2024 Jan 18. Antiviral Res. 2024. PMID: 38244889
A Study of the Activity of Adamantyl Amines against Mutant Influenza A M2 Channels Identified a Polycyclic Cage Amine Triple Blocker, Explored by Molecular Dynamics Simulations and Solid-State NMR.
Stampolaki Μ, Hoffmann A, Tekwani K, Georgiou K, Tzitzoglaki C, Ma C, Becker S, Schmerer P, Döring K, Stylianakis I, Turcu AL, Wang J, Vázquez S, Andreas LB, Schmidtke M, Kolocouris A. Stampolaki Μ, et al. Among authors: schmidtke m. ChemMedChem. 2023 Aug 15;18(16):e202300182. doi: 10.1002/cmdc.202300182. Epub 2023 Jul 25. ChemMedChem. 2023. PMID: 37377066
Upregulation of the AMPK-FOXO1-PDK4 pathway is a primary mechanism of pyruvate dehydrogenase activity reduction in tafazzin-deficient cells.
Liang Z, Ralph-Epps T, Schmidtke MW, Lazcano P, Denis SW, Balážová M, Teixeira J NDR, Chakkour M, Hazime S, Ren M, Schlame M, Houtkooper RH, Greenberg ML. Liang Z, et al. Among authors: schmidtke mw. Sci Rep. 2024 May 20;14(1):11497. doi: 10.1038/s41598-024-62262-1. Sci Rep. 2024. PMID: 38769106 Free PMC article.
Upregulation of the AMPK-FOXO1-PDK4 pathway is a primary mechanism of pyruvate dehydrogenase activity reduction and leads to increased glucose uptake in tafazzin-deficient cells.
Liang Z, Ralph-Epps T, Schmidtke MW, Lazcano P, Denis SW, Balážová M, Chakkour M, Hazime S, Ren M, Schlame M, Houtkooper RH, Greenberg ML. Liang Z, et al. Among authors: schmidtke mw. bioRxiv [Preprint]. 2024 Feb 4:2024.02.03.578755. doi: 10.1101/2024.02.03.578755. bioRxiv. 2024. PMID: 38352304 Free PMC article. Updated. Preprint.
Anomalous peroxidase activity of cytochrome c is the primary pathogenic target in Barth syndrome.
Kagan VE, Tyurina YY, Mikulska-Ruminska K, Damschroder D, Vieira Neto E, Lasorsa A, Kapralov AA, Tyurin VA, Amoscato AA, Samovich SN, Souryavong AB, Dar HH, Ramim A, Liang Z, Lazcano P, Ji J, Schmidtke MW, Kiselyov K, Korkmaz A, Vladimirov GK, Artyukhova MA, Rampratap P, Cole LK, Niyatie A, Baker EK, Peterson J, Hatch GM, Atkinson J, Vockley J, Kühn B, Wessells R, van der Wel PCA, Bahar I, Bayir H, Greenberg ML. Kagan VE, et al. Among authors: schmidtke mw. Nat Metab. 2023 Dec;5(12):2184-2205. doi: 10.1038/s42255-023-00926-4. Epub 2023 Nov 23. Nat Metab. 2023. PMID: 37996701
124 results