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Distinct use of super-enhancer elements controls cell type-specific CD25 transcription and function.
Spolski R, Li P, Chandra V, Shin B, Goel S, Sakamoto K, Liu C, Oh J, Ren M, Enomoto Y, West EE, Christensen SM, Wan ECK, Ge M, Lin JX, Yan B, Kazemian M, Yu ZX, Nagao K, Vijayanand P, Rothenberg EV, Leonard WJ. Spolski R, et al. Among authors: leonard wj. Sci Immunol. 2023 Nov 3;8(89):eadi8217. doi: 10.1126/sciimmunol.adi8217. Epub 2023 Nov 3. Sci Immunol. 2023. PMID: 37922339 Free PMC article.
Transcriptional Heterogeneity Overcomes Super-Enhancer Disrupting Drug Combinations in Multiple Myeloma.
Welsh SJ, Barwick BG, Meermeier EW, Riggs DL, Shi CX, Zhu YX, Sharik ME, Du MT, Abrego Rocha LD, Garbitt VM, Stein CK, Petit JL, Meurice N, Tafoya Alvarado Y, Fonseca R, Todd KT, Brown S, Hammond ZJ, Cuc NH, Wittenberg C, Herzog C, Roschke AV, Demchenko YN, Chen WD, Li P, Liao W, Leonard WJ, Lonial S, Bahlis NJ, Neri P, Boise LH, Chesi M, Bergsagel PL. Welsh SJ, et al. Among authors: leonard wj. Blood Cancer Discov. 2024 Jan 8;5(1):34-55. doi: 10.1158/2643-3230.BCD-23-0062. Blood Cancer Discov. 2024. PMID: 37767768 Free PMC article.
Transcription factor EGR2 controls homing and pathogenicity of TH17 cells in the central nervous system.
Gao Y, Wang Y, Chauss D, Villarino AV, Link VM, Nagashima H, Spinner CA, Koparde VN, Bouladoux N, Abers MS, Break TJ, Chopp LB, Park JH, Zhu J, Wiest DL, Leonard WJ, Lionakis MS, O'Shea JJ, Afzali B, Belkaid Y, Lazarevic V. Gao Y, et al. Among authors: leonard wj. Nat Immunol. 2023 Aug;24(8):1331-1344. doi: 10.1038/s41590-023-01553-7. Epub 2023 Jul 13. Nat Immunol. 2023. PMID: 37443284 Free PMC article.
Engineered cytokine/antibody fusion proteins improve delivery of IL-2 to pro-inflammatory cells and promote antitumor activity.
Leonard EK, Tomala J, Gould JR, Leff MI, Lin JX, Li P, Porter MJ, Johansen ER, Thompson L, Cao SD, Henclova T, Huliciak M, Vaněk O, Kovar M, Leonard WJ, Spangler JB. Leonard EK, et al. Among authors: leonard wj. bioRxiv [Preprint]. 2023 May 4:2023.05.03.539272. doi: 10.1101/2023.05.03.539272. bioRxiv. 2023. PMID: 37205604 Free PMC article. Preprint.
TSLP-targeting therapy: Beyond allergy?
Ebina-Shibuya R, Leonard WJ. Ebina-Shibuya R, et al. Among authors: leonard wj. Clin Transl Med. 2023 May;13(5):e1241. doi: 10.1002/ctm2.1241. Clin Transl Med. 2023. PMID: 37165746 Free PMC article. No abstract available.
357 results