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Targeting Casein Kinase 1 Delta Sensitizes Pancreatic and Bladder Cancer Cells to Gemcitabine Treatment by Upregulating Deoxycytidine Kinase.
Vena F, Bayle S, Nieto A, Quereda V, Aceti M, Frydman SM, Sansil SS, Grant W, Monastyrskyi A, McDonald P, Roush WR, Teng M, Duckett D. Vena F, et al. Among authors: monastyrskyi a. Mol Cancer Ther. 2020 Aug;19(8):1623-1635. doi: 10.1158/1535-7163.MCT-19-0997. Epub 2020 May 19. Mol Cancer Ther. 2020. PMID: 32430484 Free PMC article.
Therapeutic Targeting of CDK12/CDK13 in Triple-Negative Breast Cancer.
Quereda V, Bayle S, Vena F, Frydman SM, Monastyrskyi A, Roush WR, Duckett DR. Quereda V, et al. Among authors: monastyrskyi a. Cancer Cell. 2019 Nov 11;36(5):545-558.e7. doi: 10.1016/j.ccell.2019.09.004. Epub 2019 Oct 24. Cancer Cell. 2019. PMID: 31668947 Free article.
Chemical Proteomics with Novel Fully Functionalized Fragments and Stringent Target Prioritization Identifies the Glutathione-Dependent Isomerase GSTZ1 as a Lung Cancer Target.
Liao Y, Chin Chan S, Welsh EA, Fang B, Sun L, Schönbrunn E, Koomen JM, Duckett DR, Haura EB, Monastyrskyi A, Rix U. Liao Y, et al. Among authors: monastyrskyi a. ACS Chem Biol. 2023 Feb 17;18(2):251-264. doi: 10.1021/acschembio.2c00587. Epub 2023 Jan 11. ACS Chem Biol. 2023. PMID: 36630201
The dual PI3Kδ/CK1ε inhibitor umbralisib exhibits unique immunomodulatory effects on CLL T cells.
Maharaj K, Powers JJ, Achille A, Mediavilla-Varela M, Gamal W, Burger KL, Fonseca R, Jiang K, Miskin HP, Maryanski D, Monastyrskyi A, Duckett DR, Roush WR, Cleveland JL, Sahakian E, Pinilla-Ibarz J. Maharaj K, et al. Among authors: monastyrskyi a. Blood Adv. 2020 Jul 14;4(13):3072-3084. doi: 10.1182/bloodadvances.2020001800. Blood Adv. 2020. PMID: 32634240 Free PMC article.
Orally bioavailable 6-chloro-7-methoxy-4(1H)-quinolones efficacious against multiple stages of Plasmodium.
Cross RM, Flanigan DL, Monastyrskyi A, LaCrue AN, Sáenz FE, Maignan JR, Mutka TS, White KL, Shackleford DM, Bathurst I, Fronczek FR, Wojtas L, Guida WC, Charman SA, Burrows JN, Kyle DE, Manetsch R. Cross RM, et al. Among authors: monastyrskyi a. J Med Chem. 2014 Nov 13;57(21):8860-79. doi: 10.1021/jm500942v. Epub 2014 Oct 22. J Med Chem. 2014. PMID: 25148516 Free PMC article.
20 results