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DNA polymerase ε and δ variants drive mutagenesis in polypurine tracts in human tumors.
Cell Rep. 2024 Jan 23;43(1):113655. doi: 10.1016/j.celrep.2023.113655. Epub 2024 Jan 13.
Cell Rep. 2024.
PMID: 38219146
Free PMC article.
Replicative DNA polymerase defects in human cancers: Consequences, mechanisms, and implications for therapy.
Barbari SR, Shcherbakova PV.
Barbari SR, et al.
DNA Repair (Amst). 2017 Aug;56:16-25. doi: 10.1016/j.dnarep.2017.06.003. Epub 2017 Jun 9.
DNA Repair (Amst). 2017.
PMID: 28687338
Free PMC article.
Review.
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Functional Analysis of Cancer-Associated DNA Polymerase ε Variants in Saccharomyces cerevisiae.
Barbari SR, Kane DP, Moore EA, Shcherbakova PV.
Barbari SR, et al.
G3 (Bethesda). 2018 Mar 2;8(3):1019-1029. doi: 10.1534/g3.118.200042.
G3 (Bethesda). 2018.
PMID: 29352080
Free PMC article.
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Enhanced polymerase activity permits efficient synthesis by cancer-associated DNA polymerase ϵ variants at low dNTP levels.
Barbari SR, Beach AK, Markgren JG, Parkash V, Moore EA, Johansson E, Shcherbakova PV.
Barbari SR, et al.
Nucleic Acids Res. 2022 Aug 12;50(14):8023-8040. doi: 10.1093/nar/gkac602.
Nucleic Acids Res. 2022.
PMID: 35822874
Free PMC article.
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Homologous Recombination Repair Truncations Predict Hypermutation in Microsatellite Stable Colorectal and Endometrial Tumors.
Lee M, Eng G, Barbari SR, Deshpande V, Shcherbakova PV, Gala MK.
Lee M, et al. Among authors: barbari sr.
Clin Transl Gastroenterol. 2020 Mar;11(3):e00149. doi: 10.14309/ctg.0000000000000149.
Clin Transl Gastroenterol. 2020.
PMID: 32352724
Free PMC article.
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Compensation for the absence of the catalytically active half of DNA polymerase ε in yeast by positively selected mutations in CDC28.
Stepchenkova EI, Zhuk AS, Cui J, Tarakhovskaya ER, Barbari SR, Shcherbakova PV, Polev DE, Fedorov R, Poliakov E, Rogozin IB, Lada AG, Pavlov YI.
Stepchenkova EI, et al. Among authors: barbari sr.
Genetics. 2021 Jun 24;218(2):iyab060. doi: 10.1093/genetics/iyab060.
Genetics. 2021.
PMID: 33844024
Free PMC article.
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