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Coronary Disease Association With ADAMTS7 Is Due to Protease Activity.
Mizoguchi T, MacDonald BT, Bhandary B, Popp NR, Laprise D, Arduini A, Lai D, Zhu QM, Xing Y, Kaushik VK, Kathiresan S, Ellinor PT. Mizoguchi T, et al. Among authors: macdonald bt. Circ Res. 2021 Aug 6;129(4):458-470. doi: 10.1161/CIRCRESAHA.121.319163. Epub 2021 Jun 28. Circ Res. 2021. PMID: 34176299 Free PMC article.
Rare, Damaging DNA Variants in CORIN and Risk of Coronary Artery Disease: Insights From Functional Genomics and Large-Scale Sequencing Analyses.
Wang M, Lee-Kim VS, Atri DS, Elowe NH, Yu J, Garvie CW, Won HH, Hadaya JE, MacDonald BT, Trindade K, Melander O, Rader DJ, Natarajan P, Kathiresan S, Kaushik VK, Khera AV, Gupta RM. Wang M, et al. Among authors: macdonald bt. Circ Genom Precis Med. 2021 Oct;14(5):e003399. doi: 10.1161/CIRCGEN.121.003399. Epub 2021 Oct 1. Circ Genom Precis Med. 2021. PMID: 34592835 Free PMC article. Clinical Trial.
Endothelial ARHGEF26 is an angiogenic factor promoting VEGF signalling.
Zhu QM, MacDonald BT, Mizoguchi T, Chaffin M, Leed A, Arduini A, Malolepsza E, Lage K, Kaushik VK, Kathiresan S, Ellinor PT. Zhu QM, et al. Among authors: macdonald bt. Cardiovasc Res. 2022 Oct 21;118(13):2833-2846. doi: 10.1093/cvr/cvab344. Cardiovasc Res. 2022. PMID: 34849650 Free PMC article.
TAILS Identifies Candidate Substrates and Biomarkers of ADAMTS7, a Therapeutic Protease Target in Coronary Artery Disease.
MacDonald BT, Keshishian H, Mundorff CC, Arduini A, Lai D, Bendinelli K, Popp NR, Bhandary B, Clauser KR, Specht H, Elowe NH, Laprise D, Xing Y, Kaushik VK, Carr SA, Ellinor PT. MacDonald BT, et al. Mol Cell Proteomics. 2022 Apr;21(4):100223. doi: 10.1016/j.mcpro.2022.100223. Epub 2022 Mar 11. Mol Cell Proteomics. 2022. PMID: 35283288 Free PMC article.
Lrp5 functions in bone to regulate bone mass.
Cui Y, Niziolek PJ, MacDonald BT, Zylstra CR, Alenina N, Robinson DR, Zhong Z, Matthes S, Jacobsen CM, Conlon RA, Brommage R, Liu Q, Mseeh F, Powell DR, Yang QM, Zambrowicz B, Gerrits H, Gossen JA, He X, Bader M, Williams BO, Warman ML, Robling AG. Cui Y, et al. Among authors: macdonald bt. Nat Med. 2011 Jun;17(6):684-91. doi: 10.1038/nm.2388. Epub 2011 May 22. Nat Med. 2011. PMID: 21602802 Free PMC article.
43 results