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A cis-regulatory element regulates ERAP2 expression through autoimmune disease risk SNPs.
Venema WJ, Hiddingh S, van Loosdregt J, Bowes J, Balliu B, de Boer JH, Ossewaarde-van Norel J, Thompson SD, Langefeld CD, de Ligt A, van der Veken LT, Krijger PHL, de Laat W, Kuiper JJW. Venema WJ, et al. Among authors: van loosdregt j. Cell Genom. 2024 Jan 10;4(1):100460. doi: 10.1016/j.xgen.2023.100460. Epub 2023 Dec 5. Cell Genom. 2024. PMID: 38190099 Free PMC article.
Recombinant Interleukin-1 Receptor Antagonist Is an Effective First-Line Treatment Strategy in New-Onset Systemic Juvenile Idiopathic Arthritis, Irrespective of HLA-DRB1 Background and IL1RN Variants.
Erkens RGA, Calis JJA, Verwoerd A, De Roock S, Ter Haar NM, Den Engelsman G, Van der Veken LT, Ernst RF, Van Deutekom HWM, Pickering A, Scholman RC, Jansen MHA, Swart JF, Sinha R, Roth J, Schulert GS, Grom AA, Van Loosdregt J, Vastert SJ. Erkens RGA, et al. Among authors: van loosdregt j. Arthritis Rheumatol. 2024 Jan;76(1):119-129. doi: 10.1002/art.42656. Epub 2023 Nov 6. Arthritis Rheumatol. 2024. PMID: 37471469
Inhibition of Super-Enhancer Activity in Autoinflammatory Site-Derived T Cells Reduces Disease-Associated Gene Expression.
Peeters JG, Vervoort SJ, Tan SC, Mijnheer G, de Roock S, Vastert SJ, Nieuwenhuis EE, van Wijk F, Prakken BJ, Creyghton MP, Coffer PJ, Mokry M, van Loosdregt J. Peeters JG, et al. Among authors: van loosdregt j, van wijk f. Cell Rep. 2015 Sep 29;12(12):1986-96. doi: 10.1016/j.celrep.2015.08.046. Epub 2015 Sep 17. Cell Rep. 2015. PMID: 26387944 Free article.
Autoimmune disease-associated gene expression is reduced by BET-inhibition.
Peeters JG, Vervoort SJ, Mijnheer G, de Roock S, Vastert SJ, Nieuwenhuis EE, van Wijk F, Prakken BJ, Mokry M, van Loosdregt J. Peeters JG, et al. Among authors: van loosdregt j, van wijk f. Genom Data. 2015 Nov 7;7:14-7. doi: 10.1016/j.gdata.2015.11.004. eCollection 2016 Mar. Genom Data. 2015. PMID: 26981351 Free PMC article.
Dutch juvenile idiopathic arthritis patients, carers and clinicians create a research agenda together following the James Lind Alliance method: a study protocol.
Schoemaker CG, Armbrust W, Swart JF, Vastert SJ, van Loosdregt J, Verwoerd A, Whiting C, Cowan K, Olsder W, Versluis E, van Vliet R, Fernhout MJ, Bookelman SL, Cappon J, van den Berg JM, Schatorjé E, Muller PCEH, Kamphuis S, de Boer J, Lelieveld OTHM, van der Net J, Jongsma KR, van Rensen A, Dedding C, Wulffraat NM. Schoemaker CG, et al. Among authors: van der net j, van rensen a, van loosdregt j, van den berg jm, van vliet r. Pediatr Rheumatol Online J. 2018 Sep 15;16(1):57. doi: 10.1186/s12969-018-0276-3. Pediatr Rheumatol Online J. 2018. PMID: 30219072 Free PMC article. Review.
Dutch patients, caregivers and healthcare professionals generate first nationwide research agenda for juvenile idiopathic arthritis.
Verwoerd A, Armbrust W, Cowan K, van den Berg L, de Boer J, Bookelman S, Britstra M, Cappon J, Certan M, Dedding C, van den Haspel K, Muller PH, Jongsma K, Lelieveld O, van Loosdregt J, Olsder W, Rocha J, Schatorjé E, Schouten N, Swart JF, Vastert S, Walter M, Schoemaker CG. Verwoerd A, et al. Among authors: van den berg l, van loosdregt j, van den haspel k. Pediatr Rheumatol Online J. 2021 Apr 7;19(1):52. doi: 10.1186/s12969-021-00540-2. Pediatr Rheumatol Online J. 2021. PMID: 33827608 Free PMC article.
N6-Methyladenosine Directly Regulates CD40L Expression in CD4+ T Lymphocytes.
van Vroonhoven ECN, Picavet LW, Scholman RC, van den Dungen NAM, Mokry M, Evers A, Lebbink RJ, Calis JJA, Vastert SJ, van Loosdregt J. van Vroonhoven ECN, et al. Among authors: van loosdregt j. Biology (Basel). 2023 Jul 14;12(7):1004. doi: 10.3390/biology12071004. Biology (Basel). 2023. PMID: 37508433 Free PMC article.
Pyruvate metabolism controls chromatin remodeling during CD4+ T cell activation.
Mocholi E, Russo L, Gopal K, Ramstead AG, Hochrein SM, Vos HR, Geeven G, Adegoke AO, Hoekstra A, van Es RM, Pittol JR, Vastert S, Rutter J, Radstake T, van Loosdregt J, Berkers C, Mokry M, Anderson CC, O'Connell RM, Vaeth M, Ussher J, Burgering BMT, Coffer PJ. Mocholi E, et al. Among authors: van loosdregt j. Cell Rep. 2023 Jun 27;42(6):112583. doi: 10.1016/j.celrep.2023.112583. Epub 2023 Jun 1. Cell Rep. 2023. PMID: 37267106 Free article.
47 results