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A cis-regulatory element regulates ERAP2 expression through autoimmune disease risk SNPs.
Venema WJ, Hiddingh S, van Loosdregt J, Bowes J, Balliu B, de Boer JH, Ossewaarde-van Norel J, Thompson SD, Langefeld CD, de Ligt A, van der Veken LT, Krijger PHL, de Laat W, Kuiper JJW. Venema WJ, et al. Among authors: de laat w. Cell Genom. 2024 Jan 10;4(1):100460. doi: 10.1016/j.xgen.2023.100460. Epub 2023 Dec 5. Cell Genom. 2024. PMID: 38190099 Free PMC article.
CTCF Binding Polarity Determines Chromatin Looping.
de Wit E, Vos ES, Holwerda SJ, Valdes-Quezada C, Verstegen MJ, Teunissen H, Splinter E, Wijchers PJ, Krijger PH, de Laat W. de Wit E, et al. Among authors: de laat w. Mol Cell. 2015 Nov 19;60(4):676-84. doi: 10.1016/j.molcel.2015.09.023. Epub 2015 Oct 29. Mol Cell. 2015. PMID: 26527277 Free article.
Building regulatory landscapes reveals that an enhancer can recruit cohesin to create contact domains, engage CTCF sites and activate distant genes.
Rinzema NJ, Sofiadis K, Tjalsma SJD, Verstegen MJAM, Oz Y, Valdes-Quezada C, Felder AK, Filipovska T, van der Elst S, de Andrade Dos Ramos Z, Han R, Krijger PHL, de Laat W. Rinzema NJ, et al. Among authors: de laat w. Nat Struct Mol Biol. 2022 Jun;29(6):563-574. doi: 10.1038/s41594-022-00787-7. Epub 2022 Jun 16. Nat Struct Mol Biol. 2022. PMID: 35710842 Free PMC article.
The pluripotent genome in three dimensions is shaped around pluripotency factors.
de Wit E, Bouwman BA, Zhu Y, Klous P, Splinter E, Verstegen MJ, Krijger PH, Festuccia N, Nora EP, Welling M, Heard E, Geijsen N, Poot RA, Chambers I, de Laat W. de Wit E, et al. Among authors: de laat w. Nature. 2013 Sep 12;501(7466):227-31. doi: 10.1038/nature12420. Epub 2013 Jul 24. Nature. 2013. PMID: 23883933
Cause and Consequence of Tethering a SubTAD to Different Nuclear Compartments.
Wijchers PJ, Krijger PHL, Geeven G, Zhu Y, Denker A, Verstegen MJAM, Valdes-Quezada C, Vermeulen C, Janssen M, Teunissen H, Anink-Groenen LCM, Verschure PJ, de Laat W. Wijchers PJ, et al. Among authors: de laat w. Mol Cell. 2016 Feb 4;61(3):461-473. doi: 10.1016/j.molcel.2016.01.001. Epub 2016 Jan 28. Mol Cell. 2016. PMID: 26833089 Free PMC article.
Multi-contact 4C: long-molecule sequencing of complex proximity ligation products to uncover local cooperative and competitive chromatin topologies.
Vermeulen C, Allahyar A, Bouwman BAM, Krijger PHL, Verstegen MJAM, Geeven G, Valdes-Quezada C, Renkens I, Straver R, Kloosterman WP, de Ridder J, de Laat W. Vermeulen C, et al. Among authors: de laat w, de ridder j. Nat Protoc. 2020 Feb;15(2):364-397. doi: 10.1038/s41596-019-0242-7. Epub 2020 Jan 13. Nat Protoc. 2020. PMID: 31932773
140 results