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Eomes-dependent mitochondrial regulation promotes survival of pathogenic CD4+ T cells during inflammation.
Joulia E, Michieletto MF, Agesta A, Peillex C, Girault V, Le Dorze AL, Peroceschi R, Bucciarelli F, Szelechowski M, Chaubet A, Hakim N, Marrocco R, Lhuillier E, Lebeurrier M, Argüello RJ, Saoudi A, El Costa H, Adoue V, Walzer T, Sarry JE, Dejean AS. Joulia E, et al. Among authors: arguello rj. J Exp Med. 2024 Feb 5;221(2):e20230449. doi: 10.1084/jem.20230449. Epub 2024 Jan 8. J Exp Med. 2024. PMID: 38189779
Mitochondrial inhibitors circumvent adaptive resistance to venetoclax and cytarabine combination therapy in acute myeloid leukemia.
Bosc C, Saland E, Bousard A, Gadaud N, Sabatier M, Cognet G, Farge T, Boet E, Gotanègre M, Aroua N, Mouchel PL, Polley N, Larrue C, Kaphan E, Picard M, Sahal A, Jarrou L, Tosolini M, Rambow F, Cabon F, Nicot N, Poillet-Perez L, Wang Y, Su X, Fovez Q, Kluza J, Argüello RJ, Mazzotti C, Avet-Loiseau H, Vergez F, Tamburini J, Fournié JJ, Tiong IS, Wei AH, Kaoma T, Marine JC, Récher C, Stuani L, Joffre C, Sarry JE. Bosc C, et al. Among authors: arguello rj. Nat Cancer. 2021 Nov;2(11):1204-1223. doi: 10.1038/s43018-021-00264-y. Epub 2021 Nov 11. Nat Cancer. 2021. PMID: 35122057
ILC precursors differentiate into metabolically distinct ILC1-like cells during Mycobacterium tuberculosis infection.
Corral D, Charton A, Krauss MZ, Blanquart E, Levillain F, Lefrançais E, Sneperger T, Vahlas Z, Girard JP, Eberl G, Poquet Y, Guéry JC, Argüello RJ, Belkaid Y, Mayer-Barber KD, Hepworth MR, Neyrolles O, Hudrisier D. Corral D, et al. Among authors: arguello rj. Cell Rep. 2022 Apr 19;39(3):110715. doi: 10.1016/j.celrep.2022.110715. Cell Rep. 2022. PMID: 35443177 Free PMC article.
OXPHOS promotes apoptotic resistance and cellular persistence in TH17 cells in the periphery and tumor microenvironment.
Hong HS, Mbah NE, Shan M, Loesel K, Lin L, Sajjakulnukit P, Correa LO, Andren A, Lin J, Hayashi A, Magnuson B, Chen J, Li Z, Xie Y, Zhang L, Goldstein DR, Carty SA, Lei YL, Opipari AW, Argüello RJ, Kryczek I, Kamada N, Zou W, Franchi L, Lyssiotis CA. Hong HS, et al. Among authors: arguello rj. Sci Immunol. 2022 Nov 25;7(77):eabm8182. doi: 10.1126/sciimmunol.abm8182. Epub 2022 Nov 18. Sci Immunol. 2022. PMID: 36399539 Free PMC article.
Biallelic NFATC1 mutations cause an inborn error of immunity with impaired CD8+ T-cell function and perturbed glycolysis.
Kostel Bal S, Giuliani S, Block J, Repiscak P, Hafemeister C, Shahin T, Kasap N, Ransmayr B, Miao Y, van de Wetering C, Frohne A, Jimenez Heredia R, Schuster M, Zoghi S, Hertlein V, Thian M, Bykov A, Babayeva R, Bilgic Eltan S, Karakoc-Aydiner E, Shaw LE, Chowdhury I, Varjosalo M, Argüello RJ, Farlik M, Ozen A, Serfling E, Dupré L, Bock C, Halbritter F, Hannich JT, Castanon I, Kraakman MJ, Baris S, Boztug K. Kostel Bal S, et al. Among authors: arguello rj. Blood. 2023 Aug 31;142(9):827-845. doi: 10.1182/blood.2022018303. Blood. 2023. PMID: 37249233
Distinct metabolic programs established in the thymus control effector functions of γδ T cell subsets in tumor microenvironments.
Lopes N, McIntyre C, Martin S, Raverdeau M, Sumaria N, Kohlgruber AC, Fiala GJ, Agudelo LZ, Dyck L, Kane H, Douglas A, Cunningham S, Prendeville H, Loftus R, Carmody C, Pierre P, Kellis M, Brenner M, Argüello RJ, Silva-Santos B, Pennington DJ, Lynch L. Lopes N, et al. Among authors: arguello rj. Nat Immunol. 2021 Feb;22(2):179-192. doi: 10.1038/s41590-020-00848-3. Epub 2021 Jan 18. Nat Immunol. 2021. PMID: 33462452 Free PMC article.
Proteostasis in dendritic cells is controlled by the PERK signaling axis independently of ATF4.
Mendes A, Gigan JP, Rodriguez Rodrigues C, Choteau SA, Sanseau D, Barros D, Almeida C, Camosseto V, Chasson L, Paton AW, Paton JC, Argüello RJ, Lennon-Duménil AM, Gatti E, Pierre P. Mendes A, et al. Among authors: arguello rj. Life Sci Alliance. 2020 Dec 21;4(2):e202000865. doi: 10.26508/lsa.202000865. Print 2021 Feb. Life Sci Alliance. 2020. PMID: 33443099 Free PMC article.
40 results