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327 results

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Sculpting conducting nanopore size and shape through de novo protein design.
Berhanu S, Majumder S, Müntener T, Whitehouse J, Berner C, Bera AK, Kang A, Liang B, Khan GN, Sankaran B, Tamm LK, Brockwell DJ, Hiller S, Radford SE, Baker D, Vorobieva AA. Berhanu S, et al. Among authors: radford se. bioRxiv [Preprint]. 2023 Dec 20:2023.12.20.572500. doi: 10.1101/2023.12.20.572500. bioRxiv. 2023. PMID: 38187764 Free PMC article. Preprint.
Toward quantitative super-resolution methods for cryo-CLEM.
Zanetti-Domingues LC, Hirsch M, Wang L, Eastwood TA, Baker K, Mulvihill DP, Radford S, Horne J, White P, Bateman B. Zanetti-Domingues LC, et al. Methods Cell Biol. 2024;187:249-292. doi: 10.1016/bs.mcb.2024.02.028. Epub 2024 Mar 12. Methods Cell Biol. 2024. PMID: 38705627
Single molecule delivery into living cells.
Chau CC, Maffeo CM, Aksimentiev A, Radford SE, Hewitt EW, Actis P. Chau CC, et al. Among authors: radford se. Nat Commun. 2024 May 23;15(1):4403. doi: 10.1038/s41467-024-48608-3. Nat Commun. 2024. PMID: 38782907 Free PMC article.
A Targetable N-Terminal Motif Orchestrates α-Synuclein Oligomer-to-Fibril Conversion.
Santos J, Cuellar J, Pallarès I, Byrd EJ, Lends A, Moro F, Abdul-Shukkoor MB, Pujols J, Velasco-Carneros L, Sobott F, Otzen DE, Calabrese AN, Muga A, Pedersen JS, Loquet A, Valpuesta JM, Radford SE, Ventura S. Santos J, et al. Among authors: radford se. J Am Chem Soc. 2024 May 8;146(18):12702-12711. doi: 10.1021/jacs.4c02262. Epub 2024 Apr 29. J Am Chem Soc. 2024. PMID: 38683963 Free PMC article.
Darobactin B Stabilises a Lateral-Closed Conformation of the BAM Complex in E. coli Cells.
Haysom SF, Machin J, Whitehouse JM, Horne JE, Fenn K, Ma Y, El Mkami H, Böhringer N, Schäberle TF, Ranson NA, Radford SE, Pliotas C. Haysom SF, et al. Among authors: radford se. Angew Chem Weinheim Bergstr Ger. 2023 Aug 21;135(34):e202218783. doi: 10.1002/ange.202218783. Epub 2023 May 31. Angew Chem Weinheim Bergstr Ger. 2023. PMID: 38515502 Free PMC article.
Local structural preferences in shaping tau amyloid polymorphism.
Louros N, Wilkinson M, Tsaka G, Ramakers M, Morelli C, Garcia T, Gallardo R, D'Haeyer S, Goossens V, Audenaert D, Thal DR, Mackenzie IR, Rademakers R, Ranson NA, Radford SE, Rousseau F, Schymkowitz J. Louros N, et al. Among authors: radford se. Nat Commun. 2024 Feb 3;15(1):1028. doi: 10.1038/s41467-024-45429-2. Nat Commun. 2024. PMID: 38310108 Free PMC article.
Substitution of Met-38 to Ile in γ-synuclein found in two patients with amyotrophic lateral sclerosis induces aggregation into amyloid.
Aubrey LD, Ninkina N, Ulamec SM, Abramycheva NY, Vasili E, Devine OM, Wilkinson M, Mackinnon E, Limorenko G, Walko M, Muwanga S, Amadio L, Peters OM, Illarioshkin SN, Outeiro TF, Ranson NA, Brockwell DJ, Buchman VL, Radford SE. Aubrey LD, et al. Among authors: radford se. Proc Natl Acad Sci U S A. 2024 Jan 9;121(2):e2309700120. doi: 10.1073/pnas.2309700120. Epub 2024 Jan 3. Proc Natl Acad Sci U S A. 2024. PMID: 38170745 Free PMC article.
Structural evolution of fibril polymorphs during amyloid assembly.
Wilkinson M, Xu Y, Thacker D, Taylor AIP, Fisher DG, Gallardo RU, Radford SE, Ranson NA. Wilkinson M, et al. Among authors: radford se. Cell. 2023 Dec 21;186(26):5798-5811.e26. doi: 10.1016/j.cell.2023.11.025. Cell. 2023. PMID: 38134875 Free article.
327 results