Andreotti AH - Search Results

1

Impact of the clinically approved BTK inhibitors on the conformation of full-length BTK and analysis of the development of BTK resistance mutations in chronic lymphocytic leukemia.

Joseph RE, Wales TE, Jayne S, Britton RG, Fulton DB, Engen JR, Dyer MJS, Andreotti AH. Joseph RE, et al. Among authors: andreotti ah. bioRxiv [Preprint]. 2023 Dec 18:2023.12.18.572223. doi: 10.1101/2023.12.18.572223. bioRxiv. 2023. PMID: 38187560 Free PMC article. Preprint.

2

Differential impact of BTK active site inhibitors on the conformational state of full-length BTK.

Joseph RE, Amatya N, Fulton DB, Engen JR, Wales TE, Andreotti A. Joseph RE, et al. Elife. 2020 Nov 23;9:e60470. doi: 10.7554/eLife.60470. Elife. 2020. PMID: 33226337 Free PMC article.

3

The Conformational State of the BTK Substrate PLCγ Contributes to Ibrutinib Resistance.

Joseph RE, Lowe J, Fulton DB, Engen JR, Wales TE, Andreotti AH. Joseph RE, et al. Among authors: andreotti ah. J Mol Biol. 2022 Mar 15;434(5):167422. doi: 10.1016/j.jmb.2021.167422. Epub 2021 Dec 23. J Mol Biol. 2022. PMID: 34954235 Free PMC article.

4

Conformational heterogeneity of the BTK PHTH domain drives multiple regulatory states.

Lin DY, Kueffer LE, Juneja P, Wales TE, Engen JR, Andreotti AH. Lin DY, et al. Among authors: andreotti ah. bioRxiv [Preprint]. 2023 Dec 15:2023.06.02.543453. doi: 10.1101/2023.06.02.543453. bioRxiv. 2023. PMID: 37786675 Free PMC article. Updated. Preprint.

5

Mechanism and functional significance of Itk autophosphorylation.

Joseph RE, Fulton DB, Andreotti AH. Joseph RE, et al. Among authors: andreotti ah. J Mol Biol. 2007 Nov 9;373(5):1281-92. doi: 10.1016/j.jmb.2007.08.060. Epub 2007 Aug 31. J Mol Biol. 2007. PMID: 17897671 Free PMC article.

6

SH2-dependent autophosphorylation within the Tec family kinase Itk.

Joseph RE, Severin A, Min L, Fulton DB, Andreotti AH. Joseph RE, et al. Among authors: andreotti ah. J Mol Biol. 2009 Aug 7;391(1):164-77. doi: 10.1016/j.jmb.2009.06.023. Epub 2009 Jun 11. J Mol Biol. 2009. PMID: 19523959 Free PMC article.

7

Substrate recognition of PLCγ1 via a specific docking surface on Itk.

Xie Q, Joseph RE, Fulton DB, Andreotti AH. Xie Q, et al. Among authors: andreotti ah. J Mol Biol. 2013 Feb 22;425(4):683-96. doi: 10.1016/j.jmb.2012.10.023. Epub 2012 Dec 3. J Mol Biol. 2013. PMID: 23219468 Free PMC article.

8

A conserved isoleucine maintains the inactive state of Bruton's tyrosine kinase.

Boyken SE, Chopra N, Xie Q, Joseph RE, Wales TE, Fulton DB, Engen JR, Jernigan RL, Andreotti AH. Boyken SE, et al. Among authors: andreotti ah. J Mol Biol. 2014 Oct 23;426(21):3656-69. doi: 10.1016/j.jmb.2014.08.018. Epub 2014 Sep 2. J Mol Biol. 2014. PMID: 25193673 Free PMC article.

9

Achieving a Graded Immune Response: BTK Adopts a Range of Active/Inactive Conformations Dictated by Multiple Interdomain Contacts.

Joseph RE, Wales TE, Fulton DB, Engen JR, Andreotti AH. Joseph RE, et al. Among authors: andreotti ah. Structure. 2017 Oct 3;25(10):1481-1494.e4. doi: 10.1016/j.str.2017.07.014. Epub 2017 Aug 31. Structure. 2017. PMID: 28867612 Free PMC article.

10

Lipid-targeting pleckstrin homology domain turns its autoinhibitory face toward the TEC kinases.

Amatya N, Wales TE, Kwon A, Yeung W, Joseph RE, Fulton DB, Kannan N, Engen JR, Andreotti AH. Amatya N, et al. Among authors: andreotti ah. Proc Natl Acad Sci U S A. 2019 Oct 22;116(43):21539-21544. doi: 10.1073/pnas.1907566116. Epub 2019 Oct 7. Proc Natl Acad Sci U S A. 2019. PMID: 31591208 Free PMC article.

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