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Interplay between temporal and spatial dispersion of repolarization in the initiation and perpetuation of torsades de pointes in the chronic atrioventricular block dog.
Smoczyńska A, Aarnink EW, Dunnink A, Bossu A, van Weperen VYH, Meijborg VMF, Beekman HDM, Coronel R, Vos MA. Smoczyńska A, et al. Among authors: beekman hdm. Am J Physiol Heart Circ Physiol. 2021 Sep 1;321(3):H569-H576. doi: 10.1152/ajpheart.00945.2020. Epub 2021 Aug 6. Am J Physiol Heart Circ Physiol. 2021. PMID: 34355987 Free article.
Short-term Variability of Repolarization Is Superior to Other Repolarization Parameters in the Evaluation of Diverse Antiarrhythmic Interventions in the Chronic Atrioventricular Block Dog.
Bossu A, Varkevisser R, Beekman HDM, Houtman MJC, van der Heyden MAG, Vos MA. Bossu A, et al. Among authors: beekman hdm. J Cardiovasc Pharmacol. 2017 Jun;69(6):398-407. doi: 10.1097/FJC.0000000000000488. J Cardiovasc Pharmacol. 2017. PMID: 28574954 Free PMC article. Review.
Selective late sodium current inhibitor GS-458967 suppresses Torsades de Pointes by mostly affecting perpetuation but not initiation of the arrhythmia.
Bossu A, Houtman MJC, Meijborg VMF, Varkevisser R, Beekman HDM, Dunnink A, de Bakker JMT, Mollova N, Rajamani S, Belardinelli L, van der Heyden MAG, Vos MA. Bossu A, et al. Among authors: beekman hdm. Br J Pharmacol. 2018 Jun;175(12):2470-2482. doi: 10.1111/bph.14217. Epub 2018 May 6. Br J Pharmacol. 2018. PMID: 29582428 Free PMC article.
LUF7244, an allosteric modulator/activator of Kv 11.1 channels, counteracts dofetilide-induced torsades de pointes arrhythmia in the chronic atrioventricular block dog model.
Qile M, Beekman HDM, Sprenkeler DJ, Houtman MJC, van Ham WB, Stary-Weinzinger A, Beyl S, Hering S, van den Berg DJ, de Lange ECM, Heitman LH, IJzerman AP, Vos MA, van der Heyden MAG. Qile M, et al. Among authors: beekman hdm. Br J Pharmacol. 2019 Oct;176(19):3871-3885. doi: 10.1111/bph.14798. Epub 2019 Aug 30. Br J Pharmacol. 2019. PMID: 31339551 Free PMC article.
High-rate pacing guided by short-term variability of repolarization prevents imminent ventricular arrhythmias automatically by an implantable cardioverter-defibrillator in the chronic atrioventricular block dog model.
Smoczyńska A, Loen V, Aranda A, Beekman HDM, Meine M, Vos MA. Smoczyńska A, et al. Among authors: beekman hdm. Heart Rhythm. 2020 Dec;17(12):2078-2085. doi: 10.1016/j.hrthm.2020.07.023. Epub 2020 Jul 22. Heart Rhythm. 2020. PMID: 32710972 Free article.
18 results