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Delivery to, and Reactivation of, the p53 Pathway in Cancer Cells Using a Grafted Cyclotide Conjugated with a Cell-Penetrating Peptide.
J Med Chem. 2024 Jan 25;67(2):1197-1208. doi: 10.1021/acs.jmedchem.3c01682. Epub 2024 Jan 4.
J Med Chem. 2024.
PMID: 38174919
Cyclic peptide scaffold with ability to stabilize and deliver a helical cell-impermeable cargo across membranes of cultured cancer cells.
Lawrence N, Philippe GJ, Harvey PJ, Condon ND, Benfield AH, Cheneval O, Craik DJ, Troeira Henriques S.
Lawrence N, et al. Among authors: philippe gj.
RSC Chem Biol. 2020 Oct 20;1(5):405-420. doi: 10.1039/d0cb00099j. eCollection 2020 Dec 1.
RSC Chem Biol. 2020.
PMID: 34458771
Free PMC article.
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Angler Peptides: Macrocyclic Conjugates Inhibit p53:MDM2/X Interactions and Activate Apoptosis in Cancer Cells.
Philippe GJ, Mittermeier A, Lawrence N, Huang YH, Condon ND, Loewer A, Craik DJ, Henriques ST.
Philippe GJ, et al.
ACS Chem Biol. 2021 Feb 19;16(2):414-428. doi: 10.1021/acschembio.0c00988. Epub 2021 Feb 3.
ACS Chem Biol. 2021.
PMID: 33533253
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Converting peptides into drugs targeting intracellular protein-protein interactions.
Philippe GJB, Craik DJ, Henriques ST.
Philippe GJB, et al.
Drug Discov Today. 2021 Jun;26(6):1521-1531. doi: 10.1016/j.drudis.2021.01.022. Epub 2021 Jan 29.
Drug Discov Today. 2021.
PMID: 33524603
Review.
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Cell Membrane Composition Drives Selectivity and Toxicity of Designed Cyclic Helix-Loop-Helix Peptides with Cell Penetrating and Tumor Suppressor Properties.
Philippe GJ, Gaspar D, Sheng C, Huang YH, Benfield AH, Condon ND, Weidmann J, Lawrence N, Löwer A, Castanho MARB, Craik DJ, Troeira Henriques S.
Philippe GJ, et al.
ACS Chem Biol. 2019 Sep 20;14(9):2071-2087. doi: 10.1021/acschembio.9b00593. Epub 2019 Aug 21.
ACS Chem Biol. 2019.
PMID: 31390185
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