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Identification and Optimization of a Novel HIV-1 Integrase Inhibitor.
Adu-Ampratwum D, Pan Y, Koneru PC, Antwi J, Hoyte AC, Kessl J, Griffin PR, Kvaratskhelia M, Fuchs JR, Larue RC. Adu-Ampratwum D, et al. ACS Omega. 2022 Jan 24;7(5):4482-4491. doi: 10.1021/acsomega.1c06378. eCollection 2022 Feb 8. ACS Omega. 2022. PMID: 35155940 Free PMC article.
The Competitive Interplay between Allosteric HIV-1 Integrase Inhibitor BI/D and LEDGF/p75 during the Early Stage of HIV-1 Replication Adversely Affects Inhibitor Potency.
Feng L, Dharmarajan V, Serrao E, Hoyte A, Larue RC, Slaughter A, Sharma A, Plumb MR, Kessl JJ, Fuchs JR, Bushman FD, Engelman AN, Griffin PR, Kvaratskhelia M. Feng L, et al. Among authors: kessl jj. ACS Chem Biol. 2016 May 20;11(5):1313-21. doi: 10.1021/acschembio.6b00167. Epub 2016 Mar 2. ACS Chem Biol. 2016. PMID: 26910179 Free PMC article.
A New Class of Allosteric HIV-1 Integrase Inhibitors Identified by Crystallographic Fragment Screening of the Catalytic Core Domain.
Patel D, Antwi J, Koneru PC, Serrao E, Forli S, Kessl JJ, Feng L, Deng N, Levy RM, Fuchs JR, Olson AJ, Engelman AN, Bauman JD, Kvaratskhelia M, Arnold E. Patel D, et al. Among authors: kessl jj. J Biol Chem. 2016 Nov 4;291(45):23569-23577. doi: 10.1074/jbc.M116.753384. Epub 2016 Sep 19. J Biol Chem. 2016. PMID: 27645997 Free PMC article.
36 results