Asada H - Search Results

1

Crystal structure reveals the binding mode and selectivity of a photoswitchable ligand for the adenosine A_2A receptor.

Araya T, Matsuba Y, Suzuki H, Doura T, Nuemket N, Nango E, Yamamoto M, Im D, Asada H, Kiyonaka S, Iwata S. Araya T, et al. Among authors: asada h. Biochem Biophys Res Commun. 2024 Feb 5;695:149393. doi: 10.1016/j.bbrc.2023.149393. Epub 2023 Dec 20. Biochem Biophys Res Commun. 2024. PMID: 38171234 Free article.

2

Structure of the dopamine D₂ receptor in complex with the antipsychotic drug spiperone.

Im D, Inoue A, Fujiwara T, Nakane T, Yamanaka Y, Uemura T, Mori C, Shiimura Y, Kimura KT, Asada H, Nomura N, Tanaka T, Yamashita A, Nango E, Tono K, Kadji FMN, Aoki J, Iwata S, Shimamura T. Im D, et al. Among authors: asada h. Nat Commun. 2020 Dec 22;11(1):6442. doi: 10.1038/s41467-020-20221-0. Nat Commun. 2020. PMID: 33353947 Free PMC article.

3

Structural insights into the agonists binding and receptor selectivity of human histamine H₄ receptor.

Im D, Kishikawa JI, Shiimura Y, Hisano H, Ito A, Fujita-Fujiharu Y, Sugita Y, Noda T, Kato T, Asada H, Iwata S. Im D, et al. Among authors: asada h. Nat Commun. 2023 Oct 20;14(1):6538. doi: 10.1038/s41467-023-42260-z. Nat Commun. 2023. PMID: 37863901 Free PMC article.

4

The Crystal Structure of Angiotensin II Type 2 Receptor with Endogenous Peptide Hormone.

Asada H, Inoue A, Ngako Kadji FM, Hirata K, Shiimura Y, Im D, Shimamura T, Nomura N, Iwanari H, Hamakubo T, Kusano-Arai O, Hisano H, Uemura T, Suno C, Aoki J, Iwata S. Asada H, et al. Structure. 2020 Apr 7;28(4):418-425.e4. doi: 10.1016/j.str.2019.12.003. Epub 2019 Dec 30. Structure. 2020. PMID: 31899086 Free article.

5

Structure of an antagonist-bound ghrelin receptor reveals possible ghrelin recognition mode.

Shiimura Y, Horita S, Hamamoto A, Asada H, Hirata K, Tanaka M, Mori K, Uemura T, Kobayashi T, Iwata S, Kojima M. Shiimura Y, et al. Among authors: asada h. Nat Commun. 2020 Aug 19;11(1):4160. doi: 10.1038/s41467-020-17554-1. Nat Commun. 2020. PMID: 32814772 Free PMC article.

6

Endogenous agonist-bound S1PR3 structure reveals determinants of G protein-subtype bias.

Maeda S, Shiimura Y, Asada H, Hirata K, Luo F, Nango E, Tanaka N, Toyomoto M, Inoue A, Aoki J, Iwata S, Hagiwara M. Maeda S, et al. Among authors: asada h. Sci Adv. 2021 Jun 9;7(24):eabf5325. doi: 10.1126/sciadv.abf5325. Print 2021 Jun. Sci Adv. 2021. PMID: 34108205 Free PMC article.

7

Molecular basis for anti-insomnia drug design from structure of lemborexant-bound orexin 2 receptor.

Asada H, Im D, Hotta Y, Yasuda S, Murata T, Suno R, Iwata S. Asada H, et al. Structure. 2022 Dec 1;30(12):1582-1589.e4. doi: 10.1016/j.str.2022.11.001. Epub 2022 Nov 22. Structure. 2022. PMID: 36417909 Free article.

8

Structures of the 5-HT_2A receptor in complex with the antipsychotics risperidone and zotepine.

Kimura KT, Asada H, Inoue A, Kadji FMN, Im D, Mori C, Arakawa T, Hirata K, Nomura Y, Nomura N, Aoki J, Iwata S, Shimamura T. Kimura KT, et al. Among authors: asada h. Nat Struct Mol Biol. 2019 Feb;26(2):121-128. doi: 10.1038/s41594-018-0180-z. Epub 2019 Feb 4. Nat Struct Mol Biol. 2019. PMID: 30723326

9

Ligand binding to human prostaglandin E receptor EP₄ at the lipid-bilayer interface.

Toyoda Y, Morimoto K, Suno R, Horita S, Yamashita K, Hirata K, Sekiguchi Y, Yasuda S, Shiroishi M, Shimizu T, Urushibata Y, Kajiwara Y, Inazumi T, Hotta Y, Asada H, Nakane T, Shiimura Y, Nakagita T, Tsuge K, Yoshida S, Kuribara T, Hosoya T, Sugimoto Y, Nomura N, Sato M, Hirokawa T, Kinoshita M, Murata T, Takayama K, Yamamoto M, Narumiya S, Iwata S, Kobayashi T. Toyoda Y, et al. Among authors: asada h. Nat Chem Biol. 2019 Jan;15(1):18-26. doi: 10.1038/s41589-018-0131-3. Epub 2018 Dec 3. Nat Chem Biol. 2019. PMID: 30510193

10

Crystal structure of the human angiotensin II type 2 receptor bound to an angiotensin II analog.

Asada H, Horita S, Hirata K, Shiroishi M, Shiimura Y, Iwanari H, Hamakubo T, Shimamura T, Nomura N, Kusano-Arai O, Uemura T, Suno C, Kobayashi T, Iwata S. Asada H, et al. Nat Struct Mol Biol. 2018 Jul;25(7):570-576. doi: 10.1038/s41594-018-0079-8. Epub 2018 Jul 2. Nat Struct Mol Biol. 2018. PMID: 29967536

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