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Structural modification of C2-substituents on 1,4-bis(arylsulfonamido)benzene or naphthalene-N,N'-diacetic acid derivatives as potent inhibitors of the Keap1-Nrf2 protein-protein interaction.
Eur J Med Chem. 2024 Feb 5;265:116104. doi: 10.1016/j.ejmech.2023.116104. Epub 2023 Dec 27.
Eur J Med Chem. 2024.
PMID: 38159482
Discovery of disubstituted xylylene derivatives as small molecule direct inhibitors of Keap1-Nrf2 protein-protein interaction.
Abed DA, Lee S, Hu L.
Abed DA, et al.
Bioorg Med Chem. 2020 Mar 15;28(6):115343. doi: 10.1016/j.bmc.2020.115343. Epub 2020 Jan 31.
Bioorg Med Chem. 2020.
PMID: 32046917
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Optimization of 1,4-bis(arylsulfonamido)naphthalene-N,N'-diacetic acids as inhibitors of Keap1-Nrf2 protein-protein interaction to suppress neuroinflammation.
Abed DA, Lee S, Wen X, Ali AR, Mangipudy V, Aleksunes LM, Hu L.
Abed DA, et al.
Bioorg Med Chem. 2021 Aug 15;44:116300. doi: 10.1016/j.bmc.2021.116300. Epub 2021 Jul 1.
Bioorg Med Chem. 2021.
PMID: 34252790
Free PMC article.
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Structure-activity relationships of 1,4-bis(arylsulfonamido)-benzene or naphthalene-N,N'-diacetic acids with varying C2-substituents as inhibitors of Keap1-Nrf2 protein-protein interaction.
Lee S, Abed DA, Nguyen MU, Verzi MP, Hu L.
Lee S, et al. Among authors: abed da.
Eur J Med Chem. 2022 Jul 5;237:114380. doi: 10.1016/j.ejmech.2022.114380. Epub 2022 Apr 13.
Eur J Med Chem. 2022.
PMID: 35462166
Free PMC article.
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Optimization of the C2 substituents on the 1,4-bis(arylsulfonamido)naphthalene-N,N'-diacetic acid scaffold for better inhibition of Keap1-Nrf2 protein-protein interaction.
Abed DA, Ali AR, Lee S, Nguyen MU, Verzi MP, Hu L.
Abed DA, et al.
Eur J Med Chem. 2023 Apr 5;252:115302. doi: 10.1016/j.ejmech.2023.115302. Epub 2023 Mar 22.
Eur J Med Chem. 2023.
PMID: 36989811
Free PMC article.
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Discovery of direct inhibitors of Keap1-Nrf2 protein-protein interaction as potential therapeutic and preventive agents.
Abed DA, Goldstein M, Albanyan H, Jin H, Hu L.
Abed DA, et al.
Acta Pharm Sin B. 2015 Jul;5(4):285-99. doi: 10.1016/j.apsb.2015.05.008. Epub 2015 Jul 2.
Acta Pharm Sin B. 2015.
PMID: 26579458
Free PMC article.
Review.
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Development of a Homogeneous Time-Resolved Fluorescence Resonance Energy Transfer (TR-FRET) Assay for the Inhibition of Keap1-Nrf2 Protein-Protein Interaction.
Lee S, Abed DA, Beamer LJ, Hu L.
Lee S, et al. Among authors: abed da.
SLAS Discov. 2021 Jan;26(1):100-112. doi: 10.1177/2472555220935816. Epub 2020 Jun 22.
SLAS Discov. 2021.
PMID: 32564647
Free PMC article.
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