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B56δ long-disordered arms form a dynamic PP2A regulation interface coupled with global allostery and Jordan's syndrome mutations.
Wu CG, Balakrishnan VK, Merrill RA, Parihar PS, Konovolov K, Chen YC, Xu Z, Wei H, Sundaresan R, Cui Q, Wadzinski BE, Swingle MR, Musiyenko A, Chung WK, Honkanen RE, Suzuki A, Huang X, Strack S, Xing Y. Wu CG, et al. Among authors: chen yc. Proc Natl Acad Sci U S A. 2024 Jan 2;121(1):e2310727120. doi: 10.1073/pnas.2310727120. Epub 2023 Dec 27. Proc Natl Acad Sci U S A. 2024. PMID: 38150499 Free PMC article.
Extended regulation interface coupled to the allosteric network and disease mutations in the PP2A-B56δ holoenzyme.
Wu CG, Balakrishnan VK, Parihar PS, Konovolov K, Chen YC, Merrill RA, Wei H, Carragher B, Sundaresan R, Cui Q, Wadzinski BE, Swingle MR, Musiyenko A, Honkanen R, Chung WK, Suzuki A, Strack S, Huang X, Xing Y. Wu CG, et al. Among authors: chen yc. bioRxiv [Preprint]. 2023 Apr 5:2023.03.09.530109. doi: 10.1101/2023.03.09.530109. bioRxiv. 2023. PMID: 37066309 Free PMC article. Preprint.
Mass Balance, Metabolic Pathways, Absolute Bioavailability, And Pharmacokinetics of Giredestrant In Healthy Subjects.
Kshirsagar S, Chen YC, Yu J, Gates MR, Kawakatsu S, Khojasteh SC, Ma S, Musib L, Malhi V, Osaghae U, Wang J, Cho S, Tang Y, Zhang D, Zhao W, De Bruyn T. Kshirsagar S, et al. Among authors: chen yc. Drug Metab Dispos. 2024 Jun 4:DMD-AR-2024-001688. doi: 10.1124/dmd.124.001688. Online ahead of print. Drug Metab Dispos. 2024. PMID: 38834357 Free article.
Chromosome-level genome assemblies of 2 hemichordates provide new insights into deuterostome origin and chromosome evolution.
Lin CY, Marlétaz F, Pérez-Posada A, Martínez-García PM, Schloissnig S, Peluso P, Conception GT, Bump P, Chen YC, Chou C, Lin CY, Fan TP, Tsai CT, Gómez Skarmeta JL, Tena JJ, Lowe CJ, Rank DR, Rokhsar DS, Yu K Jr, Su YH. Lin CY, et al. Among authors: chen yc. PLoS Biol. 2024 Jun 3;22(6):e3002661. doi: 10.1371/journal.pbio.3002661. Online ahead of print. PLoS Biol. 2024. PMID: 38829909 Free article.
8,673 results