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Exposure to fluoride exacerbates the cognitive deficit of diabetic patients living in areas with endemic fluorosis, as well as of rats with type 2 diabetes induced by streptozotocin via a mechanism that may involve excessive activation of the poly(ADP ribose) polymerase-1/P53 pathway.
Xiang J, Qi XL, Cao K, Ran LY, Zeng XX, Xiao X, Liao W, He WW, Hong W, He Y, Guan ZZ. Xiang J, et al. Among authors: guan zz. Sci Total Environ. 2024 Feb 20;912:169512. doi: 10.1016/j.scitotenv.2023.169512. Epub 2023 Dec 23. Sci Total Environ. 2024. PMID: 38145685
The consequences of reducing expression of the alpha7 nicotinic receptor by RNA interference and of stimulating its activity with an alpha7 agonist in SH-SY5Y cells indicate that this receptor plays a neuroprotective role in connection with the pathogenesis of Alzheimer's disease.
Qi XL, Nordberg A, Xiu J, Guan ZZ. Qi XL, et al. Among authors: guan zz. Neurochem Int. 2007 Nov-Dec;51(6-7):377-83. doi: 10.1016/j.neuint.2007.04.002. Epub 2007 Apr 8. Neurochem Int. 2007. PMID: 17493709
244 results