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Identification of an inhibitory pocket in falcilysin provides a new avenue for malaria drug development.
Cell Chem Biol. 2024 Apr 18;31(4):743-759.e8. doi: 10.1016/j.chembiol.2024.03.002. Epub 2024 Apr 8.
Cell Chem Biol. 2024.
PMID: 38593807
Identification and structural validation of purine nucleoside phosphorylase from Plasmodium falciparum as a target of MMV000848.
Chung Z, Lin J, Wirjanata G, Dziekan JM, El Sahili A, Preiser PR, Bozdech Z, Lescar J.
Chung Z, et al. Among authors: dziekan jm.
J Biol Chem. 2024 Jan;300(1):105586. doi: 10.1016/j.jbc.2023.105586. Epub 2023 Dec 21.
J Biol Chem. 2024.
PMID: 38141766
Free PMC article.
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Genetic validation of PfFKBP35 as an antimalarial drug target.
Thommen BT, Dziekan JM, Achcar F, Tjia S, Passecker A, Buczak K, Gumpp C, Schmidt A, Rottmann M, Grüring C, Marti M, Bozdech Z, Brancucci NMB.
Thommen BT, et al. Among authors: dziekan jm.
Elife. 2023 Nov 7;12:RP86975. doi: 10.7554/eLife.86975.
Elife. 2023.
PMID: 37934560
Free PMC article.
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Plasmodium falciparum Eukaryotic Translation Initiation Factor 3 is Stabilized by Quinazoline-Quinoline Bisubstrate Inhibitors.
Dobrescu I, Hammam E, Dziekan JM, Claës A, Halby L, Preiser P, Bozdech Z, Arimondo PB, Scherf A, Nardella F.
Dobrescu I, et al. Among authors: dziekan jm.
ACS Infect Dis. 2023 Jun 9;9(6):1257-1266. doi: 10.1021/acsinfecdis.3c00127. Epub 2023 May 22.
ACS Infect Dis. 2023.
PMID: 37216290
Free PMC article.
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Short tandem repeat polymorphism in the promoter region of cyclophilin 19B drives its transcriptional upregulation and contributes to drug resistance in the malaria parasite Plasmodium falciparum.
Kucharski M, Wirjanata G, Nayak S, Boentoro J, Dziekan JM, Assisi C, van der Pluijm RW, Miotto O, Mok S, Dondorp AM, Bozdech Z.
Kucharski M, et al. Among authors: dziekan jm.
PLoS Pathog. 2023 Jan 25;19(1):e1011118. doi: 10.1371/journal.ppat.1011118. eCollection 2023 Jan.
PLoS Pathog. 2023.
PMID: 36696458
Free PMC article.
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Human peroxiredoxin 6 is essential for malaria parasites and provides a host-based drug target.
Wagner MP, Formaglio P, Gorgette O, Dziekan JM, Huon C, Berneburg I, Rahlfs S, Barale JC, Feinstein SI, Fisher AB, Ménard D, Bozdech Z, Amino R, Touqui L, Chitnis CE.
Wagner MP, et al. Among authors: dziekan jm.
Cell Rep. 2022 Jun 14;39(11):110923. doi: 10.1016/j.celrep.2022.110923.
Cell Rep. 2022.
PMID: 35705035
Free article.
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Cellular thermal shift assay for the identification of drug-target interactions in the Plasmodium falciparum proteome.
Dziekan JM, Wirjanata G, Dai L, Go KD, Yu H, Lim YT, Chen L, Wang LC, Puspita B, Prabhu N, Sobota RM, Nordlund P, Bozdech Z.
Dziekan JM, et al.
Nat Protoc. 2020 Jun;15(6):1881-1921. doi: 10.1038/s41596-020-0310-z. Epub 2020 Apr 27.
Nat Protoc. 2020.
PMID: 32341577
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Identifying purine nucleoside phosphorylase as the target of quinine using cellular thermal shift assay.
Dziekan JM, Yu H, Chen D, Dai L, Wirjanata G, Larsson A, Prabhu N, Sobota RM, Bozdech Z, Nordlund P.
Dziekan JM, et al.
Sci Transl Med. 2019 Jan 2;11(473):eaau3174. doi: 10.1126/scitranslmed.aau3174.
Sci Transl Med. 2019.
PMID: 30602534
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