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Biallelic NUDT2 variants defective in mRNA decapping cause a neurodevelopmental disease.
Husain RA, Jiao X, Hennings JC, Giesecke J, Palsule G, Beck-Wödl S, Osmanović D, Bjørgo K, Mir A, Ilyas M, Abbasi SM, Efthymiou S, Dominik N, Maroofian R, Houlden H, Rankin J, Pagnamenta AT, Nashabat M, Altwaijri W, Alfadhel M, Umair M, Khouj E, Reardon W, El-Hattab AW, Mekki M, Houge G, Beetz C, Bauer P, Putoux A, Lesca G, Sanlaville D, Alkuraya FS, Taylor RW, Mentzel HJ, Hübner CA, Huppke P, Hart RP, Haack TB, Kiledjian M, Rubio I. Husain RA, et al. Among authors: kiledjian m. Brain. 2024 Apr 4;147(4):1197-1205. doi: 10.1093/brain/awad434. Brain. 2024. PMID: 38141063
Recent insights into noncanonical 5' capping and decapping of RNA.
Doamekpor SK, Sharma S, Kiledjian M, Tong L. Doamekpor SK, et al. Among authors: kiledjian m. J Biol Chem. 2022 Aug;298(8):102171. doi: 10.1016/j.jbc.2022.102171. Epub 2022 Jun 21. J Biol Chem. 2022. PMID: 35750211 Free PMC article. Review.
Xrn1 is a deNADding enzyme modulating mitochondrial NAD-capped RNA.
Sharma S, Yang J, Grudzien-Nogalska E, Shivas J, Kwan KY, Kiledjian M. Sharma S, et al. Among authors: kiledjian m. Nat Commun. 2022 Feb 16;13(1):889. doi: 10.1038/s41467-022-28555-7. Nat Commun. 2022. PMID: 35173156 Free PMC article.
mRNA-Decapping Associated DcpS Enzyme Controls Critical Steps of Neuronal Development.
Salamon I, Palsule G, Luo X, Roque A, Tucai S, Khosla I, Volk N, Liu W, Cui H, Pozzo VD, Zalamea P, Jiao X, D'Arcangelo G, Hart RP, Rasin MR, Kiledjian M. Salamon I, et al. Among authors: kiledjian m. Cereb Cortex. 2022 Mar 30;32(7):1494-1507. doi: 10.1093/cercor/bhab302. Cereb Cortex. 2022. PMID: 34467373 Free PMC article.
SOD1 regulates ribosome biogenesis in KRAS mutant non-small cell lung cancer.
Wang X, Zhang H, Sapio R, Yang J, Wong J, Zhang X, Guo JY, Pine S, Van Remmen H, Li H, White E, Liu C, Kiledjian M, Pestov DG, Steven Zheng XF. Wang X, et al. Among authors: kiledjian m. Nat Commun. 2021 Apr 15;12(1):2259. doi: 10.1038/s41467-021-22480-x. Nat Commun. 2021. PMID: 33859191 Free PMC article.
Mammalian Nudix proteins cleave nucleotide metabolite caps on RNAs.
Sharma S, Grudzien-Nogalska E, Hamilton K, Jiao X, Yang J, Tong L, Kiledjian M. Sharma S, et al. Among authors: kiledjian m. Nucleic Acids Res. 2020 Jul 9;48(12):6788-6798. doi: 10.1093/nar/gkaa402. Nucleic Acids Res. 2020. PMID: 32432673 Free PMC article.
97 results