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Synthetically mannosylated antigens induce antigen-specific humoral tolerance and reduce anti-drug antibody responses to immunogenic biologics.
Wallace RP, Refvik KC, Antane JT, Brünggel K, Tremain AC, Raczy MR, Alpar AT, Nguyen M, Solanki A, Slezak AJ, Watkins EA, Lauterbach AL, Cao S, Wilson DS, Hubbell JA. Wallace RP, et al. Among authors: hubbell ja. Cell Rep Med. 2024 Jan 16;5(1):101345. doi: 10.1016/j.xcrm.2023.101345. Epub 2023 Dec 20. Cell Rep Med. 2024. PMID: 38128533 Free PMC article.
Polymersomes decorated with SARS-CoV-2 spike protein receptor binding domain elicit robust humoral and cellular immunity.
Volpatti LR, Wallace RP, Cao S, Raczy MM, Wang R, Gray LT, Alpar AT, Briquez PS, Mitrousis N, Marchell TM, Sasso MS, Nguyen M, Mansurov A, Budina E, Solanki A, Watkins EA, Schnorenberg MR, Tremain AC, Reda JW, Nicolaescu V, Furlong K, Dvorkin S, Yu SS, Manicassamy B, LaBelle JL, Tirrell MV, Randall G, Kwissa M, Swartz MA, Hubbell JA. Volpatti LR, et al. Among authors: hubbell ja. bioRxiv [Preprint]. 2021 Apr 8:2021.04.08.438884. doi: 10.1101/2021.04.08.438884. bioRxiv. 2021. PMID: 33851166 Free PMC article. Updated. Preprint.
Therapeutic synthetic and natural materials for immunoengineering.
Slezak A, Chang K, Hossainy S, Mansurov A, Rowan SJ, Hubbell JA, Guler MO. Slezak A, et al. Among authors: hubbell ja. Chem Soc Rev. 2024 Feb 19;53(4):1789-1822. doi: 10.1039/d3cs00805c. Chem Soc Rev. 2024. PMID: 38170619 Review.
SARS-CoV-2 infection induces cross-reactive autoantibodies against angiotensin II.
Briquez PS, Rouhani SJ, Yu J, Pyzer AR, Trujillo J, Dugan HL, Stamper CT, Changrob S, Sperling AI, Wilson PC, Gajewski TF, Hubbell JA, Swartz MA. Briquez PS, et al. Among authors: hubbell ja. medRxiv [Preprint]. 2021 Nov 2:2021.11.02.21265789. doi: 10.1101/2021.11.02.21265789. medRxiv. 2021. PMID: 34751272 Free PMC article. Updated. Preprint.
A serine-conjugated butyrate prodrug with high oral bioavailability suppresses autoimmune arthritis and neuroinflammation in mice.
Cao S, Budina E, Raczy MM, Solanki A, Nguyen M, Beckman TN, Reda JW, Hultgren K, Ang PS, Slezak AJ, Hesser LA, Alpar AT, Refvik KC, Shores LS, Pillai I, Wallace RP, Dhar A, Watkins EA, Hubbell JA. Cao S, et al. Among authors: hubbell ja. Nat Biomed Eng. 2024 Apr 1. doi: 10.1038/s41551-024-01190-x. Online ahead of print. Nat Biomed Eng. 2024. PMID: 38561491
LDL-Binding IL-10 Reduces Vascular Inflammation in Atherosclerotic Mice.
Volpatti LR, de Matos SN, Borjas G, Reda J, Watkins EA, Zhou Z, Nguyen M, Solanki A, Fang Y, Hubbell JA. Volpatti LR, et al. Among authors: hubbell ja. bioRxiv [Preprint]. 2024 Mar 6:2024.03.04.582839. doi: 10.1101/2024.03.04.582839. bioRxiv. 2024. PMID: 38496521 Free PMC article. Preprint.
Engineered IL-7 synergizes with IL-12 immunotherapy to prevent T cell exhaustion and promote memory without exacerbating toxicity.
Kang S, Mansurov A, Kurtanich T, Chun HR, Slezak AJ, Volpatti LR, Chang K, Wang T, Alpar AT, Refvik KC, Hansen OI, Borjas GJ, Shim HN, Hultgren KT, Gomes S, Solanki A, Ishihara J, Swartz MA, Hubbell JA. Kang S, et al. Among authors: hubbell ja. Sci Adv. 2023 Dec;9(48):eadh9879. doi: 10.1126/sciadv.adh9879. Epub 2023 Nov 29. Sci Adv. 2023. PMID: 38019919 Free PMC article.
451 results