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Synthetically mannosylated antigens induce antigen-specific humoral tolerance and reduce anti-drug antibody responses to immunogenic biologics.
Wallace RP, Refvik KC, Antane JT, Brünggel K, Tremain AC, Raczy MR, Alpar AT, Nguyen M, Solanki A, Slezak AJ, Watkins EA, Lauterbach AL, Cao S, Wilson DS, Hubbell JA. Wallace RP, et al. Among authors: alpar at. Cell Rep Med. 2024 Jan 16;5(1):101345. doi: 10.1016/j.xcrm.2023.101345. Epub 2023 Dec 20. Cell Rep Med. 2024. PMID: 38128533 Free PMC article.
Engineering Targeting Materials for Therapeutic Cancer Vaccines.
Briquez PS, Hauert S, de Titta A, Gray LT, Alpar AT, Swartz MA, Hubbell JA. Briquez PS, et al. Among authors: alpar at. Front Bioeng Biotechnol. 2020 Feb 11;8:19. doi: 10.3389/fbioe.2020.00019. eCollection 2020. Front Bioeng Biotechnol. 2020. PMID: 32117911 Free PMC article. Review.
Collagen-binding IL-12 enhances tumour inflammation and drives the complete remission of established immunologically cold mouse tumours.
Mansurov A, Ishihara J, Hosseinchi P, Potin L, Marchell TM, Ishihara A, Williford JM, Alpar AT, Raczy MM, Gray LT, Swartz MA, Hubbell JA. Mansurov A, et al. Among authors: alpar at. Nat Biomed Eng. 2020 May;4(5):531-543. doi: 10.1038/s41551-020-0549-2. Epub 2020 Apr 13. Nat Biomed Eng. 2020. PMID: 32284554 Free PMC article.
Prolonged residence of an albumin-IL-4 fusion protein in secondary lymphoid organs ameliorates experimental autoimmune encephalomyelitis.
Ishihara A, Ishihara J, Watkins EA, Tremain AC, Nguyen M, Solanki A, Katsumata K, Mansurov A, Budina E, Alpar AT, Hosseinchi P, Maillat L, Reda JW, Kageyama T, Swartz MA, Yuba E, Hubbell JA. Ishihara A, et al. Among authors: alpar at. Nat Biomed Eng. 2021 May;5(5):387-398. doi: 10.1038/s41551-020-00627-3. Epub 2020 Oct 12. Nat Biomed Eng. 2021. PMID: 33046864
Publisher Correction: Prolonged residence of an albumin-IL-4 fusion protein in secondary lymphoid organs ameliorates experimental autoimmune encephalomyelitis.
Ishihara A, Ishihara J, Watkins EA, Tremain AC, Nguyen M, Solanki A, Katsumata K, Mansurov A, Budina E, Alpar AT, Hosseinchi P, Maillat L, Reda JW, Kageyama T, Swartz MA, Yuba E, Hubbell JA. Ishihara A, et al. Among authors: alpar at. Nat Biomed Eng. 2020 Nov;4(11):1117. doi: 10.1038/s41551-020-00649-x. Nat Biomed Eng. 2020. PMID: 33093659
Suppression of Rheumatoid Arthritis by Enhanced Lymph Node Trafficking of Engineered Interleukin-10 in Murine Models.
Yuba E, Budina E, Katsumata K, Ishihara A, Mansurov A, Alpar AT, Watkins EA, Hosseinchi P, Reda JW, Lauterbach AL, Nguyen M, Solanki A, Kageyama T, Swartz MA, Ishihara J, Hubbell JA. Yuba E, et al. Among authors: alpar at. Arthritis Rheumatol. 2021 May;73(5):769-778. doi: 10.1002/art.41585. Epub 2021 Mar 8. Arthritis Rheumatol. 2021. PMID: 33169522 Free PMC article.
Polymersomes decorated with SARS-CoV-2 spike protein receptor binding domain elicit robust humoral and cellular immunity.
Volpatti LR, Wallace RP, Cao S, Raczy MM, Wang R, Gray LT, Alpar AT, Briquez PS, Mitrousis N, Marchell TM, Sasso MS, Nguyen M, Mansurov A, Budina E, Solanki A, Watkins EA, Schnorenberg MR, Tremain AC, Reda JW, Nicolaescu V, Furlong K, Dvorkin S, Yu SS, Manicassamy B, LaBelle JL, Tirrell MV, Randall G, Kwissa M, Swartz MA, Hubbell JA. Volpatti LR, et al. Among authors: alpar at. bioRxiv [Preprint]. 2021 Apr 8:2021.04.08.438884. doi: 10.1101/2021.04.08.438884. bioRxiv. 2021. PMID: 33851166 Free PMC article. Updated. Preprint.
Immunoengineering approaches for cytokine therapy.
Mansurov A, Lauterbach A, Budina E, Alpar AT, Hubbell JA, Ishihara J. Mansurov A, et al. Among authors: alpar at. Am J Physiol Cell Physiol. 2021 Aug 1;321(2):C369-C383. doi: 10.1152/ajpcell.00515.2020. Epub 2021 Jul 7. Am J Physiol Cell Physiol. 2021. PMID: 34232748 Free article.
Polymersomes Decorated with the SARS-CoV-2 Spike Protein Receptor-Binding Domain Elicit Robust Humoral and Cellular Immunity.
Volpatti LR, Wallace RP, Cao S, Raczy MM, Wang R, Gray LT, Alpar AT, Briquez PS, Mitrousis N, Marchell TM, Sasso MS, Nguyen M, Mansurov A, Budina E, Solanki A, Watkins EA, Schnorenberg MR, Tremain AC, Reda JW, Nicolaescu V, Furlong K, Dvorkin S, Yu SS, Manicassamy B, LaBelle JL, Tirrell MV, Randall G, Kwissa M, Swartz MA, Hubbell JA. Volpatti LR, et al. Among authors: alpar at. ACS Cent Sci. 2021 Aug 25;7(8):1368-1380. doi: 10.1021/acscentsci.1c00596. Epub 2021 Jul 21. ACS Cent Sci. 2021. PMID: 34466656 Free PMC article.
Generation of potent cellular and humoral immunity against SARS-CoV-2 antigens via conjugation to a polymeric glyco-adjuvant.
Gray LT, Raczy MM, Briquez PS, Marchell TM, Alpar AT, Wallace RP, Volpatti LR, Sasso MS, Cao S, Nguyen M, Mansurov A, Budina E, Watkins EA, Solanki A, Mitrousis N, Reda JW, Yu SS, Tremain AC, Wang R, Nicolaescu V, Furlong K, Dvorkin S, Manicassamy B, Randall G, Wilson DS, Kwissa M, Swartz MA, Hubbell JA. Gray LT, et al. Among authors: alpar at. Biomaterials. 2021 Nov;278:121159. doi: 10.1016/j.biomaterials.2021.121159. Epub 2021 Sep 30. Biomaterials. 2021. PMID: 34634664 Free PMC article.
21 results