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Discovery of ginisortamab, a potent and novel anti-gremlin-1 antibody in clinical development for the treatment of cancer.
MAbs. 2023 Jan-Dec;15(1):2289681. doi: 10.1080/19420862.2023.2289681. Epub 2023 Dec 12.
MAbs. 2023.
PMID: 38084840
Free PMC article.
The Chemical Synthesis of Knob Domain Antibody Fragments.
Macpherson A, Birtley JR, Broadbridge RJ, Brady K, Schulze MED, Tang Y, Joyce C, Saunders K, Bogle G, Horton J, Kelm S, Taylor RD, Franklin RJ, Selby MD, Laabei M, Wonfor T, Hold A, Stanley P, Vadysirisack D, Shi J, van den Elsen J, Lawson ADG.
Macpherson A, et al. Among authors: schulze med.
ACS Chem Biol. 2021 Sep 17;16(9):1757-1769. doi: 10.1021/acschembio.1c00472. Epub 2021 Aug 18.
ACS Chem Biol. 2021.
PMID: 34406751
Free article.
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Identification of ß-Glucocerebrosidase Activators for Glucosylceramide hydrolysis.
Schulze MED, Scholz D, Jnoff E, Hall A, Melin J, Sands ZA, Rodriguez E, Andre VM.
Schulze MED, et al.
ChemMedChem. 2024 Apr 2;19(7):e202300548. doi: 10.1002/cmdc.202300548. Epub 2024 Feb 21.
ChemMedChem. 2024.
PMID: 38381042
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Modulation of IL-17 backbone dynamics reduces receptor affinity and reveals a new inhibitory mechanism.
Shaw DJ, Waters LC, Strong SL, Schulze MED, Greetham GM, Towrie M, Parker AW, Prosser CE, Henry AJ, Lawson ADG, Carr MD, Taylor RJ, Hunt NT, Muskett FW.
Shaw DJ, et al. Among authors: schulze med.
Chem Sci. 2023 Jun 16;14(27):7524-7536. doi: 10.1039/d3sc00728f. eCollection 2023 Jul 12.
Chem Sci. 2023.
PMID: 37449080
Free PMC article.
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The allosteric modulation of complement C5 by knob domain peptides.
Macpherson A, Laabei M, Ahdash Z, Graewert MA, Birtley JR, Schulze ME, Crennell S, Robinson SA, Holmes B, Oleinikovas V, Nilsson PH, Snowden J, Ellis V, Mollnes TE, Deane CM, Svergun D, Lawson AD, van den Elsen JM.
Macpherson A, et al.
Elife. 2021 Feb 11;10:e63586. doi: 10.7554/eLife.63586.
Elife. 2021.
PMID: 33570492
Free PMC article.
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Designing Out PXR Activity on Drug Discovery Projects: A Review of Structure-Based Methods, Empirical and Computational Approaches.
Hall A, Chanteux H, Ménochet K, Ledecq M, Schulze MED.
Hall A, et al. Among authors: schulze med.
J Med Chem. 2021 May 27;64(10):6413-6522. doi: 10.1021/acs.jmedchem.0c02245. Epub 2021 May 18.
J Med Chem. 2021.
PMID: 34003642
Review.
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Optimization of 8-Hydroxyquinolines as Inhibitors of Catechol O-Methyltransferase.
Buchler I, Akuma D, Au V, Carr G, de León P, DePasquale M, Ernst G, Huang Y, Kimos M, Kolobova A, Poslusney M, Wei H, Swinnen D, Montel F, Moureau F, Jigorel E, Schulze MED, Wood M, Barrow JC.
Buchler I, et al. Among authors: schulze med.
J Med Chem. 2018 Nov 8;61(21):9647-9665. doi: 10.1021/acs.jmedchem.8b01126. Epub 2018 Oct 19.
J Med Chem. 2018.
PMID: 30272964
Free PMC article.
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