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Pharmacological modulation of septins restores calcium homeostasis and is neuroprotective in models of Alzheimer's disease.
Princen K, Van Dooren T, van Gorsel M, Louros N, Yang X, Dumbacher M, Bastiaens I, Coupet K, Dupont S, Cuveliers E, Lauwers A, Laghmouchi M, Vanwelden T, Carmans S, Van Damme N, Duhamel H, Vansteenkiste S, Prerad J, Pipeleers K, Rodiers O, De Ridder L, Claes S, Busschots Y, Pringels L, Verhelst V, Debroux E, Brouwer M, Lievens S, Tavernier J, Farinelli M, Hughes-Asceri S, Voets M, Winderickx J, Wera S, de Wit J, Schymkowitz J, Rousseau F, Zetterberg H, Cummings JL, Annaert W, Cornelissen T, De Winter H, De Witte K, Fivaz M, Griffioen G. Princen K, et al. Among authors: de winter h. Science. 2024 May 31;384(6699):eadd6260. doi: 10.1126/science.add6260. Epub 2024 May 31. Science. 2024. PMID: 38815015
Molecule auto-correction to facilitate molecular design.
Kerstjens A, De Winter H. Kerstjens A, et al. Among authors: de winter h. J Comput Aided Mol Des. 2024 Feb 16;38(1):10. doi: 10.1007/s10822-024-00549-1. J Comput Aided Mol Des. 2024. PMID: 38363377 Free PMC article.
Highly Selective Inhibitors of Dipeptidyl Peptidase 9 (DPP9) Derived from the Clinically Used DPP4-Inhibitor Vildagliptin.
Benramdane S, De Loose J, Filippi N, Espadinha M, Beyens O, Rymenant YV, Dirkx L, Bozdag M, Feijens PB, Augustyns K, Caljon G, De Winter H, De Meester I, Van der Veken P. Benramdane S, et al. Among authors: de winter h. J Med Chem. 2023 Sep 28;66(18):12717-12738. doi: 10.1021/acs.jmedchem.3c00609. Epub 2023 Sep 18. J Med Chem. 2023. PMID: 37721854
Genomic and Phenotypic Characterization of Experimentally Selected Resistant Leishmania donovani Reveals a Role for Dynamin-1-Like Protein in the Mechanism of Resistance to a Novel Antileishmanial Compound.
Hefnawy A, Negreira G, Jara M, Cotton JA, Maes I, D'Haenens E, Imamura H, Cuypers B, Monsieurs P, Mouchtoglou C, De Winter H, Pintelon I, Timmermans JP, Berriman M, Sanders M, Martin J, de Muylder G, Dujardin JC, Sterckx YG, Domagalska MA. Hefnawy A, et al. Among authors: de winter h. mBio. 2022 Feb 22;13(1):e0326421. doi: 10.1128/mbio.03264-21. Epub 2022 Jan 11. mBio. 2022. PMID: 35012338 Free PMC article.
66 results