Schleiff MA - Search Results

1

The role of cytochrome P450 3A4-mediated metabolism in sorafenib and lapatinib hepatotoxicity.

McGill MR, Kaufman YJ, LoBianco FV, Schleiff MA, Aykin-Burns N, Miller GP. McGill MR, et al. Among authors: schleiff ma. Livers. 2023 Jun;3(2):310-321. doi: 10.3390/livers3020022. Epub 2023 Jun 19. Livers. 2023. PMID: 38037613 Free PMC article.

2

CYP2C9 and 3A4 play opposing roles in bioactivation and detoxification of diphenylamine NSAIDs.

Schleiff MA, Crosby S, Blue M, Schleiff BM, Boysen G, Miller GP. Schleiff MA, et al. Biochem Pharmacol. 2021 Dec;194:114824. doi: 10.1016/j.bcp.2021.114824. Epub 2021 Nov 5. Biochem Pharmacol. 2021. PMID: 34748821 Free PMC article.

3

Meloxicam methyl group determines enzyme specificity for thiazole bioactivation compared to sudoxicam.

Barnette DA, Schleiff MA, Datta A, Flynn N, Swamidass SJ, Miller GP. Barnette DA, et al. Among authors: schleiff ma. Toxicol Lett. 2021 Mar 1;338:10-20. doi: 10.1016/j.toxlet.2020.11.015. Epub 2020 Nov 27. Toxicol Lett. 2021. PMID: 33253783 Free PMC article.

4

Crosby SV, Ahmed IY, Osborn LR, Wang Z, Schleiff MA, Fantegrossi WE, Nagar S, Prather PL, Boysen G, Miller GP. Crosby SV, et al. Among authors: schleiff ma. Metabolites. 2022 Aug 22;12(8):773. doi: 10.3390/metabo12080773. Metabolites. 2022. PMID: 36005645 Free PMC article.

5

Dual mechanisms suppress meloxicam bioactivation relative to sudoxicam.

Barnette DA, Schleiff MA, Osborn LR, Flynn N, Matlock M, Swamidass SJ, Miller GP. Barnette DA, et al. Among authors: schleiff ma. Toxicology. 2020 Jul;440:152478. doi: 10.1016/j.tox.2020.152478. Epub 2020 May 11. Toxicology. 2020. PMID: 32437779 Free PMC article.

6

Significance of Multiple Bioactivation Pathways for Meclofenamate as Revealed through Modeling and Reaction Kinetics.

Schleiff MA, Flynn NR, Payakachat S, Schleiff BM, Pinson AO, Province DW, Swamidass SJ, Boysen G, Miller GP. Schleiff MA, et al. Among authors: schleiff bm. Drug Metab Dispos. 2021 Feb;49(2):133-141. doi: 10.1124/dmd.120.000254. Epub 2020 Nov 25. Drug Metab Dispos. 2021. PMID: 33239334 Free PMC article.

7

Impacts of diphenylamine NSAID halogenation on bioactivation risks.

Schleiff MA, Payakachat S, Schleiff BM, Swamidass SJ, Boysen G, Miller GP. Schleiff MA, et al. Toxicology. 2021 Jun 30;458:152832. doi: 10.1016/j.tox.2021.152832. Epub 2021 Jun 6. Toxicology. 2021. PMID: 34107285 Free PMC article.

8

Bioactivation of Isoxazole-Containing Bromodomain and Extra-Terminal Domain (BET) Inhibitors.

Flynn NR, Ward MD, Schleiff MA, Laurin CMC, Farmer R, Conway SJ, Boysen G, Swamidass SJ, Miller GP. Flynn NR, et al. Among authors: schleiff ma. Metabolites. 2021 Jun 15;11(6):390. doi: 10.3390/metabo11060390. Metabolites. 2021. PMID: 34203690 Free PMC article.

9

Significance of Competing Metabolic Pathways for 5F-APINACA Based on Quantitative Kinetics.

Pinson AO, Pouncey DL, Schleiff MA, Fantegrossi WE, Prather PL, Radominska-Pandya A, Boysen G, Miller GP. Pinson AO, et al. Among authors: schleiff ma. Molecules. 2020 Oct 20;25(20):4820. doi: 10.3390/molecules25204820. Molecules. 2020. PMID: 33092129 Free PMC article.

10

4-Methyl-1,2,3-Triazoles as N-Acetyl-Lysine Mimics Afford Potent BET Bromodomain Inhibitors with Improved Selectivity.

Cui H, Carlson AS, Schleiff MA, Divakaran A, Johnson JA, Buchholz CR, Zahid H, Vail NR, Shi K, Aihara H, Harki DA, Miller GP, Topczewski JJ, Pomerantz WCK. Cui H, et al. Among authors: schleiff ma. J Med Chem. 2021 Jul 22;64(14):10497-10511. doi: 10.1021/acs.jmedchem.1c00933. Epub 2021 Jul 8. J Med Chem. 2021. PMID: 34236185 Free PMC article.

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