Spanka C - Search Results

1

Discovery of Amino Alcohols as Highly Potent, Selective, and Orally Efficacious Inhibitors of Leukotriene A4 Hydrolase.

Thoma G, Markert C, Lueoend R, Miltz W, Spanka C, Bollbuck B, Wolf RM, Srinivas H, Penno CA, Kiffe M, Gajewska M, Bednarczyk D, Wieczorek G, Evans A, Beerli C, Röhn TA. Thoma G, et al. Among authors: spanka c. J Med Chem. 2023 Dec 14;66(23):16410-16425. doi: 10.1021/acs.jmedchem.3c01866. Epub 2023 Nov 28. J Med Chem. 2023. PMID: 38015154

2

Piperidyl amides as novel, potent and orally active mGlu5 receptor antagonists with anxiolytic-like activity.

Spanka C, Glatthar R, Desrayaud S, Fendt M, Orain D, Troxler T, Vranesic I. Spanka C, et al. Bioorg Med Chem Lett. 2010 Jan 1;20(1):184-8. doi: 10.1016/j.bmcl.2009.11.001. Epub 2009 Nov 5. Bioorg Med Chem Lett. 2010. PMID: 19931453

3

Discovery of 3-(2,6-dichloro-3,5-dimethoxy-phenyl)-1-{6-[4-(4-ethyl-piperazin-1-yl)-phenylamino]-pyrimidin-4-yl}-1-methyl-urea (NVP-BGJ398), a potent and selective inhibitor of the fibroblast growth factor receptor family of receptor tyrosine kinase.

Guagnano V, Furet P, Spanka C, Bordas V, Le Douget M, Stamm C, Brueggen J, Jensen MR, Schnell C, Schmid H, Wartmann M, Berghausen J, Drueckes P, Zimmerlin A, Bussiere D, Murray J, Graus Porta D. Guagnano V, et al. Among authors: spanka c. J Med Chem. 2011 Oct 27;54(20):7066-83. doi: 10.1021/jm2006222. Epub 2011 Sep 21. J Med Chem. 2011. PMID: 21936542

4

Improving the oral bioavailability of the iron chelator HBED by breaking the symmetry of the intramolecular H-bond network.

Faller B, Spanka C, Sergejew T, Tschinke V. Faller B, et al. Among authors: spanka c. J Med Chem. 2000 Apr 20;43(8):1467-75. doi: 10.1021/jm990261n. J Med Chem. 2000. PMID: 10780902

5

The discovery of potent, orally bioavailable pyrazolo and triazolopyrimidine CXCR2 receptor antagonists.

Porter DW, Bradley M, Brown Z, Canova R, Charlton S, Cox B, Hunt P, Kolarik D, Lewis S, O'Connor D, Reilly J, Spanka C, Tedaldi L, Watson SJ, Wermuth R, Press NJ. Porter DW, et al. Among authors: spanka c. Bioorg Med Chem Lett. 2014 Jan 1;24(1):72-6. doi: 10.1016/j.bmcl.2013.11.074. Epub 2013 Dec 4. Bioorg Med Chem Lett. 2014. PMID: 24332493

6

N-sulfonylanthranilic acid derivatives as allosteric inhibitors of dengue viral RNA-dependent RNA polymerase.

Yin Z, Chen YL, Kondreddi RR, Chan WL, Wang G, Ng RH, Lim JY, Lee WY, Jeyaraj DA, Niyomrattanakit P, Wen D, Chao A, Glickman JF, Voshol H, Mueller D, Spanka C, Dressler S, Nilar S, Vasudevan SG, Shi PY, Keller TH. Yin Z, et al. Among authors: spanka c. J Med Chem. 2009 Dec 24;52(24):7934-7. doi: 10.1021/jm901044z. J Med Chem. 2009. PMID: 20014868

7

Design and Synthesis of Metabolically Stable tRNA Synthetase Inhibitors Derived from Cladosporin.

Rusch M, Thevenon A, Hoepfner D, Aust T, Studer C, Patoor M, Rollin P, Livendahl M, Ranieri B, Schmitt E, Spanka C, Gademann K, Bouchez LC. Rusch M, et al. Among authors: spanka c. Chembiochem. 2019 Mar 1;20(5):644-649. doi: 10.1002/cbic.201800587. Epub 2019 Feb 4. Chembiochem. 2019. PMID: 30462880

8

Specific activation of the nuclear receptors PPARgamma and RORA by the antidiabetic thiazolidinedione BRL 49653 and the antiarthritic thiazolidinedione derivative CGP 52608.

Wiesenberg I, Chiesi M, Missbach M, Spanka C, Pignat W, Carlberg C. Wiesenberg I, et al. Among authors: spanka c. Mol Pharmacol. 1998 Jun;53(6):1131-8. Mol Pharmacol. 1998. PMID: 9614218

9

Application of microgels as polymer supports for organic synthesis: preparation of a small phthalide library, a scavenger, and a borohydride reagent.

Shimomura O, Clapham B, Spanka C, Mahajan S, Janda KD. Shimomura O, et al. Among authors: spanka c. J Comb Chem. 2002 Sep-Oct;4(5):436-41. doi: 10.1021/cc020012b. J Comb Chem. 2002. PMID: 12217015

10

A segmented flow platform for on-demand medicinal chemistry and compound synthesis in oscillating droplets.

Hwang YJ, Coley CW, Abolhasani M, Marzinzik AL, Koch G, Spanka C, Lehmann H, Jensen KF. Hwang YJ, et al. Among authors: spanka c. Chem Commun (Camb). 2017 Jun 16;53(49):6649-6652. doi: 10.1039/c7cc03584e. Chem Commun (Camb). 2017. PMID: 28585652

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