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Exploiting Hydrophobic Amino Acid Scanning to Develop Cyclic Peptide Inhibitors of the SARS-CoV-2 Main Protease with Antiviral Activity.
Harrison K, Carlos P, Ullrich S, Aggarwal A, Johansen-Leete J, Mini Sasi V, Barter I, Maxwell J, Bedding M, Larance M, Turville S, Jackson C, Norman A, Nitsche C, Payne RJ. Harrison K, et al. Among authors: payne rj. Chemistry. 2024 May 27:e202401606. doi: 10.1002/chem.202401606. Online ahead of print. Chemistry. 2024. PMID: 38801240
Position-specific N- and O-glycosylation of the reactive center loop impacts neutrophil elastase-mediated proteolysis of corticosteroid-binding globulin.
Chernykh A, Abrahams JL, Grant OC, Kambanis L, Sumer-Bayraktar Z, Ugonotti J, Kawahara R, Corcilius L, Payne RJ, Woods RJ, Thaysen-Andersen M. Chernykh A, et al. Among authors: payne rj. J Biol Chem. 2024 Jan;300(1):105519. doi: 10.1016/j.jbc.2023.105519. Epub 2023 Nov 30. J Biol Chem. 2024. PMID: 38042488 Free PMC article.
Serum albumin binding knob domains engineered within a VH framework III bispecific antibody format and as chimeric peptides.
Adams R, Joyce C, Kuravskiy M, Harrison K, Ahdash Z, Balmforth M, Chia K, Marceddu C, Coates M, Snowden J, Goursaud E, Ménochet K, van den Elsen J, Payne RJ, Lawson ADG, Scott-Tucker A, Macpherson A. Adams R, et al. Among authors: payne rj. Front Immunol. 2023 May 12;14:1170357. doi: 10.3389/fimmu.2023.1170357. eCollection 2023. Front Immunol. 2023. PMID: 37251411 Free PMC article.
Clp-targeting BacPROTACs impair mycobacterial proteostasis and survival.
Hoi DM, Junker S, Junk L, Schwechel K, Fischel K, Podlesainski D, Hawkins PME, van Geelen L, Kaschani F, Leodolter J, Morreale FE, Kleine S, Guha S, Rumpel K, Schmiedel VM, Weinstabl H, Meinhart A, Payne RJ, Kaiser M, Hartl M, Boehmelt G, Kazmaier U, Kalscheuer R, Clausen T. Hoi DM, et al. Among authors: payne rj. Cell. 2023 May 11;186(10):2176-2192.e22. doi: 10.1016/j.cell.2023.04.009. Epub 2023 May 2. Cell. 2023. PMID: 37137307 Free article.
Development of supramolecular anticoagulants with on-demand reversibility.
Dockerill M, Ford DJ, Angerani S, Alwis I, Dowman LJ, Ripoll-Rozada J, Smythe RE, Liu JST, Pereira PJB, Jackson SP, Payne RJ, Winssinger N. Dockerill M, et al. Among authors: payne rj. Nat Biotechnol. 2024 Apr 30. doi: 10.1038/s41587-024-02209-z. Online ahead of print. Nat Biotechnol. 2024. PMID: 38689027
Integrating Phenotypic and Chemoproteomic Approaches to Identify Covalent Targets of Dietary Electrophiles in Platelets.
Guan IA, Liu JST, Sawyer RC, Li X, Jiao W, Jiramongkol Y, White MD, Hagimola L, Passam FH, Tran DP, Liu X, Schoenwaelder SM, Jackson SP, Payne RJ, Liu X. Guan IA, et al. Among authors: payne rj. ACS Cent Sci. 2024 Jan 29;10(2):344-357. doi: 10.1021/acscentsci.3c00822. eCollection 2024 Feb 28. ACS Cent Sci. 2024. PMID: 38435523 Free PMC article.
382 results